Abstract
The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase I were studied. The new derivatives inhibit the activity of topoisomerase I at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals bearing P388 leukemia.
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Original Russian Text © L.G. Dezhenkova, A.N. Tevyashova, E.N. Olsuf’eva, I.D. Treshchalin, A.A. Shtil, M.N. Preobrazhenskaya, 2008, published in Bioorganicheskaya Khimiya, 2008, Vol. 34, No. 3, pp. 430–432.
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Dezhenkova, L.G., Tevyashova, A.N., Olsuf’eva, E.N. et al. Anthracycline antibiotics and their derivatives, inhibitors of topoisomerase I. Russ J Bioorg Chem 34, 387–389 (2008). https://doi.org/10.1134/S1068162008030230
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DOI: https://doi.org/10.1134/S1068162008030230