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Molecular evolution of intracellular Ca2+-dependent proteases

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Abstract

The structural features and evolutionary interrelationships of the intracellular Ca2+-dependent cysteine enzymes calpains, proteases of the family C2 (EC 3.4.22.17), are considered. A variety of identified sequences of calpains and calpain-like polypeptides found in organisms of different taxons, from the protozoa to mammals, are described. Calpains of the major evolutionary groups, typical and atypical, are classified by the analysis of their phylogenetic tree and are differentiated due to the presence of the calmodulin-like Ca2+-binding domain. It is shown that, along with enzymes having “advanced” characteristics (heterodimeric structure, presence of tissue-specific isoforms and splice variants, regulation by the endogenous inhibitor calpastatin, and others), higher organisms contain homologues of calpains of lower eukaryotes. A high degree of homology of the catalytic domain of calpains and the variable structure of other functional domains indicate that calpains are implicated in various physiological processes with the retention of their regulatory role.

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Correspondence to L. A. Bondareva.

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Original Russian Text © L.A. Bondareva, N.N. Nemova, 2008, published in Bioorganicheskaya Khimiya, 2008, Vol. 34, No. 3, pp. 295–302.

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Bondareva, L.A., Nemova, N.N. Molecular evolution of intracellular Ca2+-dependent proteases. Russ J Bioorg Chem 34, 266–273 (2008). https://doi.org/10.1134/S1068162008030023

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