Abstract
The content of sphingolipids in M3 and B16/F10 melanomas with a high metastatic potential and in Claudmanís and B16/F1 melanomas with a low metastatic potential was studied. It was shown that the content of total lipid-bound sialic acids and ganglioside GM3 in melanomas with a high metastatic potential is considerably higher than that in melanomas with a low metastatic potential. On the other hand, the ceramide to glucosylceramide molar ratio is higher in melanomas with a low metastatic potential.
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Abbreviations
- Cer:
-
ceramide
- GalCer:
-
galactosylceramide
- GlcCer:
-
glucosylceramide
- HPTLC:
-
high-performance thin-layer chromatography
- LacCer:
-
lactosyl ceramide
- Sia:
-
lipid-bound sialic acids
- SM:
-
sphingomyelin
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Original Russian Text © A.G. Kandyba, A.M. Kozlov, O.G. Somova, E.V. Dyatlovitskaya, 2008, published in Bioorganicheskaya Khimiya, 2008, Vol. 34, No. 2, pp. 252–255.
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Kandyba, A.G., Kozlov, A.M., Somova, O.G. et al. A comparative study of sphingolipids in transplanted melanomas with high and low metastatic activity. Russ J Bioorg Chem 34, 230–233 (2008). https://doi.org/10.1134/S1068162008020131
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DOI: https://doi.org/10.1134/S1068162008020131