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A comparative study of sphingolipids in transplanted melanomas with high and low metastatic activity

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Abstract

The content of sphingolipids in M3 and B16/F10 melanomas with a high metastatic potential and in Claudmanís and B16/F1 melanomas with a low metastatic potential was studied. It was shown that the content of total lipid-bound sialic acids and ganglioside GM3 in melanomas with a high metastatic potential is considerably higher than that in melanomas with a low metastatic potential. On the other hand, the ceramide to glucosylceramide molar ratio is higher in melanomas with a low metastatic potential.

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Abbreviations

Cer:

ceramide

GalCer:

galactosylceramide

GlcCer:

glucosylceramide

HPTLC:

high-performance thin-layer chromatography

LacCer:

lactosyl ceramide

Sia:

lipid-bound sialic acids

SM:

sphingomyelin

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    A. G. Kandyba, O. G. Somova & E. V. Dyatlovitskaya

  2. Institute of Experimental Diagnostics and Therapy of Tumors, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 24, Moscow, 115478, Russia

    A. M. Kozlov

Authors
  1. A. G. Kandyba
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  2. A. M. Kozlov
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  3. O. G. Somova
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  4. E. V. Dyatlovitskaya
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Corresponding author

Correspondence to E. V. Dyatlovitskaya.

Additional information

Original Russian Text © A.G. Kandyba, A.M. Kozlov, O.G. Somova, E.V. Dyatlovitskaya, 2008, published in Bioorganicheskaya Khimiya, 2008, Vol. 34, No. 2, pp. 252–255.

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Kandyba, A.G., Kozlov, A.M., Somova, O.G. et al. A comparative study of sphingolipids in transplanted melanomas with high and low metastatic activity. Russ J Bioorg Chem 34, 230–233 (2008). https://doi.org/10.1134/S1068162008020131

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  • DOI: https://doi.org/10.1134/S1068162008020131

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