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2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole analogues: Antifungal activity in vitro against Candida species

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Abstract

The antifungal activity in vitro of the newly synthesized and previously reported compounds of 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole series was evaluated. Their structures were confirmed by elemental analyses and IR, 1H and 13C NMR and mass spectra. The azole-resistant clinical isolates of Candida albicans and no-albicans Candida spp. were used in the antifungal tests. Some compounds exhibit higher activities than the comparatively studied antifungal drugs. Amino-1,3,4-thiadiazole derivatives exhibited higher (than other analogues) antifungal effects against Candida no-albicans spp. than against C. albicans. Derivatives with strong antifungal activity have a narrow range of lipophilicity values determined by the Villar approach.

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Authors and Affiliations

  1. Department of Chemistry, Agricultural University, Akademicka 15, 20-950, Lublin, Poland

    J. Matysiak

  2. Institute of Industrial Organic Chemistry, Annopol 6, 03-236, Warszawa, Poland

    Z. Malinski

Authors
  1. J. Matysiak
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  2. Z. Malinski
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Correspondence to J. Matysiak.

Additional information

Original Russian Text © J. Matysiak, Z. Malinski, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 6, pp. 640–647.

The text was submitted by the authors in English.

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Matysiak, J., Malinski, Z. 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole analogues: Antifungal activity in vitro against Candida species. Russ J Bioorg Chem 33, 594–601 (2007). https://doi.org/10.1134/S1068162007060106

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  • DOI: https://doi.org/10.1134/S1068162007060106

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