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Synthesis, structure, and biological properties of some 8α analogues of steroid estrogens with fluorine in position 2

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Abstract

A total synthesis of 8α analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17β-acetoxy-2-fluoro-3-methoxy-8α-estra-1,3,5(10)-triene. It was shown that the 8α analogues of 2-fluorosubstituted steroid estrogens have a low uterotropic activity and retain the osteoprotective and hypocholesterolemic activities.

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Authors and Affiliations

  1. Faculty of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Staryi Petergof, St. Petersburg, 198504, Russia

    V. N. Belov, V. Yu. Dudkin, E. A. Urusova, G. L. Starova, S. I. Selivanov, S. V. Nikolaev, N. D. Eshchenko, S. N. Morozkina & A. G. Shavva

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  1. V. N. Belov
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  2. V. Yu. Dudkin
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  3. E. A. Urusova
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  4. G. L. Starova
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  5. S. I. Selivanov
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  6. S. V. Nikolaev
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  7. N. D. Eshchenko
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  8. S. N. Morozkina
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  9. A. G. Shavva
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Correspondence to A. G. Shavva.

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Original Russian Text © V.N. Belov, V.Yu. Dudkin, E.A. Urusova, G.L. Starova, S.I. Selivanov, S.V. Nikolaev, N.D. Eshchenko, S.N. Morozkina, A.G. Shavva, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 3, pp. 315–323.

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Belov, V.N., Dudkin, V.Y., Urusova, E.A. et al. Synthesis, structure, and biological properties of some 8α analogues of steroid estrogens with fluorine in position 2. Russ J Bioorg Chem 33, 293–301 (2007). https://doi.org/10.1134/S1068162007030041

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  • DOI: https://doi.org/10.1134/S1068162007030041

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