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pH-sensitive cationic lipopeptides for the design of drug-delivery systems

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Abstract

Lipopeptides on the basis of L-glutamic acid and glutamine di-and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.

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Abbreviations

CMC:

critical concentration of micelle formation

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Authors and Affiliations

  1. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia

    Yu. L. Sebyakin & U. A. Budanova

Authors
  1. Yu. L. Sebyakin
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  2. U. A. Budanova
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Correspondence to Yu. L. Sebyakin.

Additional information

Original Russian Text © Yu.L. Sebyakin, U.A. Budanova, 2006, published in Bioorganicheskaya Khimiya, 2006, Vol. 32, No. 5, pp. 453–458.

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Sebyakin, Y.L., Budanova, U.A. pH-sensitive cationic lipopeptides for the design of drug-delivery systems. Russ J Bioorg Chem 32, 407–412 (2006). https://doi.org/10.1134/S1068162006050025

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  • DOI: https://doi.org/10.1134/S1068162006050025

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