Abstract
Chromosome aberration frequency in relation to population dynamics and demographic parameters was studied for six years in a bank vole population in the Middle Urals. The frequencies of structural chromosome aberrations, chromatid gaps, aneuploidy, and polyploidy in males and females and in animals of different ages did not differ significantly. In the breeding period, the frequencies of structural aberrations and changes in chromosome number increased in the somatic cells of voles. Highly significant differences between the levels of chromosome instability in different years manifested a tendency toward a negative correlation with population size.
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Bashenina, N.V., Bernshtein, A.D., Voronov, G.A., et al., Population Dynamics, in Evropeiskaya ryzhaya polevka (Bank Vole), Moscow: Nauka, 1981, pp. 245–267.
Bender, M.A., Preston, R.J., Leonard, R.C. et al., Chromosomal Aberration and Sister-Chromatid Exchange Frequencies in Peripheral Blood Lymphocytes of a Large Human Population Sample: 2. Extension of Age Range, Mutat. Res., 1989, vol. 212, no. 2, pp. 149–154.
Bocharov, Yu.S. and Vilkina, G.A., Mutations in the Karyotype and Aging, Genetika, 1966, no. 4, pp. 45–50.
Buzhievskaya, T.I., Virusindutsirovannyi mutagenez v kletkakh mlekopitayushchikh (Virus-Induced Mutagenesis in Mammalian Cells), Kiev: Naukova Dumka, 1984.
Chernyavskii, F.B., Lazutkin, A.N., and Mosin, A.F., Variations of Some Physiological and Biochemical Parameters in a Fluctuating Population of the Northern Red-Backed Vole (Clethrionomys rutilus), Izv. Akad. Nauk, Ser. Biol., 2003, no. 4, pp. 356–364.
Difilippantonio, M.J., Zhu, J., Chen, H.T. et al., DNA Repair Protein Ku80 Suppresses Chromosomal Aberrations and Malignant Transformation, Nature, 2000, vol. 404, pp. 510–514.
Dmitriev, S.G., Zakharov, V.M., and Sheftel, B.I., Cytogenetic Homeostasis and Population Density in Red-Backed Voles Clethrionomys glareolus and C. rutilus in Central Siberia, Acta Theriol., 1997, Suppl. 4, pp. 49–55.
Evsikov, V.I., Moshkin, M.P., and Gerlinskaya, L.A., Population Ecology of the Water Vole (Arvicola terrestris L.) in Western Siberia: 3. Stress and Reproduction in the Population Cycle, Sib. Ekol. Zh., 1999, no. 1, pp. 79–88.
Gaines, M. S. and Wittam, N.S., Genetic Changes in Fluctuating Vole Population: Selective Forces, Genetics, 1980, vol. 96, pp. 767–778.
Gileva, E.A., Ekologo-geneticheskii monitoring s pomoshch’yu gryzunov (ural’skii opyt) (Ecological-Genetic Monitoring with the Aid of Rodents: Ural Experience, Yekaterinburg: Ural. Gos. Univ., 1997.
Gileva, E.A., Chromatid Gap as a Marker of Mutagenic Effect of Environmental Pollution in Commensal and Wild Rodents of the Urals, Tsitol. Genet., 2002, vol. 36, no. 4, pp. 17–23.
Gileva, E.A., Polyavina, O.V., Apekina, N.S., et al., Viral Infections and Chromosome Aberrations in Bank Voles from Natural and Laboratory Populations, Genetika, 2001, vol. 37, no. 4, pp. 504–510.
Glotov, N.V., Zhivotovsky, L.A., Khovanov, N.V., and Khromov-Borisov, N.N., Biometriya (Biometry), Leningrad: Leningr. Gos. Univ., 1982.
Harvey, A.N., Costa, N.D., Savage, J.R.K., and Thacker, J., Chromosomal Aberrations Induced by Defined DNA Double-Strand Breaks: The Origin of Achromatic Lesions, Somat. Cell. Mol. Genet., 1997, vol. 23, no. 3, pp. 211–219.
Kuryshev, S.V. and Chernyavskii, F.B., Variations of Genetic Structure in Fluctuating Populations of Forest Voles (Clethrionomys, Rodentia, Cricetidae), Zool. Zh., 1988, vol. 67, no. 2, pp. 215–222.
Lezhava, T., Chromosome and Aging: Genetic Conception of Aging, Biogerontology, 2001, no. 2, pp. 253–260.
Liehr, J.G., Is Estradiol a Genotoxic Mutagenic Carcinogen?, Endocrine Rev., 2000, vol. 21, no. 1, pp. 40–54.
Lokhmiller, R.L. and Moshkin, M.P., Ecological Factors and Adaptive Significance of Immunity Variations in Small Mammals, Sib. Ekol. Zhurn., 1999, no. 1, pp. 37–58.
Mavournin, K.H., Blakey, D.H., Cimino, M.C. et al., The in vivo Micronucleus Assay in Mammalian Bone Marrow and Peripheral Blood. A Report of the U.S. Environmental Protection Agency Gene-Tox Program, Mutat. Res., 1990, vol. 239, pp. 29–80.
Morris, S.M., A Role for p53 in the Frequency and Mechanism of Mutation, Mutat. Res., 2002, vol. 511, pp. 45–62.
Olenev, G.V., Functional Determination of Ontogenetic Changes in Age Markers in Rodents and Their Application to Population Studies, Ekologiya, 1989, no. 2, pp. 19–31.
Paz-y-Mino, C., Davalos, M.V., Sanchez, M.E., et al., Should Gaps Be Included in Chromosomal Aberration Analysis? Evidence Based on the Comet Assay, Mutat. Res., 2002, vol. 516, nos. 1–2, pp. 57–61.
Polyavina, O.V., Assessment of Correlation between Sex and Age Structure, Genotoxic Potential of the Environment, and Cytogenetic Instability in House Mice in the Urals and Western Siberia, in Biota gornykh territorii: Mat. konf. molodykh uchenykh (Biota of Mountain Territories: Proc. Conference of Young Scientists), Yekaterinburg: Yekaterinburg, 2002, pp. 147–157.
Rakitin, S.B., Dynamics of Cytogenetic Instability in Bank Voles from Different Intrapopulation Groups, in Sovremennye problemy populyatsionnoi, istoricheskoi i prikladnoi ekologii: Mat. konf. molodykh uchenykh (Current Problems in Population, Historical, and Applied Ecology: Proc. Conference of Young Scientists), Yekaterinburg: Yekaterinburg, 2001, issue 2, pp. 191–199.
Rakitin, S.B., Age and Frequency of Chromosomal Mutations in Voles of the Middle Urals, in Biota gornykh territorii: Mat. konf. molodykh uchenykh (Biota of Mountain Areas: Proc. Conference of Young Scientists), Yekaterinburg: Yekaterinburg, 2002, pp. 170–176.
Roy, D. and Liehr, J.G., Estrogen, DNA Damage, and Mutations, Mutat. Res., 1999, vol. 424, pp. 107–115.
Skorova, S.V., Nazarova, G.G., and Gerlinskaya, L.A., Effect of Stress on Chromosome Aberration Frequency in the Water Vole, Izv. Sib. Otd. Ross. Akad. Nauk, 1986, no. 3, pp. 91–95.
Tamarin, R.H. and Krebs, C.J., Microtus Population Biology: 2. Genetic Changes at the Transferring Locus in Fluctuating Populations of Two Vole Species, Evolution, 1969, vol. 23, no. 2, pp. 183–211.
Tucker, J.D., Spruill, M.D., Ramsey, M.J. et al., Frequency of Spontaneous Chromosome Aberrations in Mice: Effects of Age, Mutat. Res., 1999, vol. 425, pp. 135–141.
Uryvaeva, I.V., Marshak, T.L., Zakhidov, S.T., et al., Accumulation with Age of Micronuclear Aberrations in Liver Cells of Quickly Aged Mice of SAM Line, Dokl. Akad. Nauk, 1999, vol. 368, no. 5, pp. 703–705.
Xiao, Y., Tates, A.D., Boei, J.J.W.A., and Natarajan, A.T., Aging and Diethylstilbestrol-Induced Aneuploidy in Male Germ Cells: A Transgenic Mouse Model, Chromosoma, 1998, vol. 107, pp. 507–513.
Zhigalski, O.A. and Kshnyasev, I.A., Population Cycles of the Bank Vole in the Range Optimum, Ekologiya, 2000, no. 5, pp. 376–383.
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Original Russian Text © E.A. Gileva, S.B. Rakitin, M.I. Cheprakov, 2006, published in Ekologiya, 2006, No. 4, pp. 301–307.
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Gileva, E.A., Rakitin, S.B. & Cheprakov, M.I. Genomic instability in the bank vole: Population-ecological aspects. Russ J Ecol 37, 271–277 (2006). https://doi.org/10.1134/S1067413606040096
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DOI: https://doi.org/10.1134/S1067413606040096