, Volume 61, Issue 4, pp 483–490 | Cite as

Reprocessing of Irradiated [18O]H2O under the Conditions of a PET Center

  • S. D. BrinkevichEmail author
  • V. O. Krot
  • D. I. Brinkevich
  • O. V. Tugai
  • I. P. Edimecheva
  • A. A. Ivanyukovich


The possibility of reprocessing of irradiated [18O]H2O after isolation of [18F]fluoride ion from it (regenerate) under the conditions of the cyclotron-radiochemical laboratory of an operating PET center was examined. The radionuclide and chemical composition of [18O]H2O and the degree of its enrichment in 18O before and after distillation at atmospheric pressure were studied comprehensively. The suggested method allows efficient removal of long-lived γ-emitting radionuclides (56Co, 57Co, 58Co, 65Zn, 54Mn, 51Cr) from the [18O]H2O regenerate. The distillation reduces the content of residual solvents (acetaldehyde, acetone, isopropanol, ethanol, acetonitrile), whereas the content of 3H and 18O in [18O]H2O changes within the measurement uncertainty. The distillation residues and decontamination solutions after neutralization can be jointly cemented to incorporate the γ-emitters into a compact matrix with the aim of its subsequent delivery to specialized organizations performing long-term storage and disposal of solid radioactive waste.


[18O]H2O regenerate [18F]fluoride long-lived radionuclides radiopharmaceuticals distillation tritium 


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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • S. D. Brinkevich
    • 1
    • 2
    Email author
  • V. O. Krot
    • 1
    • 2
  • D. I. Brinkevich
    • 1
    • 2
  • O. V. Tugai
    • 1
    • 2
  • I. P. Edimecheva
    • 2
  • A. A. Ivanyukovich
    • 3
  1. 1.Aleksandrov Republican Scientific and Practical Center of Oncology and Medical RadiologyMinskBelarus
  2. 2.Belarussian State UniversityMinskBelarus
  3. 3.Belarussian State Institute of MetrologyMinskBelarus

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