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Prospects for Infrared Luminescent Diagnostics of Superficially Located Neoplasms Using Ytterbium Porphyrin Complexes

  • APPLICATIONS OF RADIOTECHNOLOGY AND ELECTRONICS IN BIOLOGY AND MEDICINE
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Abstract

In this paper, we developed a promising technique for luminescent infrared (IR) diagnostics of neoplasms of visually and endoscopically accessible localization (dermatology, gynecology, dentistry) using ytterbium complexes of porphyrins. Possible mechanisms of accumulation of a pharmaceutical composition based on the ytterbium complex of 2,4-di(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP) in tumor tissues were studied. Studies on the pharmacokinetics and biodistribution of this substance in various organs and neoplasms of laboratory animals showed a significant selectivity of the accumulation of nanoparticles with ytterbium ions in tumors as early as 24 h after intravenous administration. For the purposes of luminescent IR diagnostics, a highly sensitive laser-fiber fluorimeter operating in the spectral range of 900–1100 nm was developed. Preclinical tests of the developed method of fluorescent IR cancer diagnostics were carried out and its prospects were shown.

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Funding

The work was supported by a state task of the Kotelnikov Institute of Radioengineering and Electronics, Russian Academy of Sciences.

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Authors and Affiliations

  1. Institute of Radioengineering and Electronics, Fryazino Branch, Russian Academy of Sciences, 141190, Fryazino, Moscow oblast, Russia

    I. P. Shilov, V. D. Rumyantseva & A. S. Gorshkova

  2. National Medical Research Center of Oncology, 115522, Moscow, Russia

    A. V. Ivanov

  3. Skobelin Scientific and Practical Center for Laser Medicine, Federal Medical-Biological Agency, 121165, Moscow, Russia

    A. V. Ivanov, Yu. V. Alekseev & M. V. Ryabov

  4. Pletnev City Clinical Hospital, 105077, Moscow, Russia

    A. M. Kovaleva

  5. Sechenov First Moscow State Medical University, 119435, Moscow, Russia

    M. I. Kovalev

Authors
  1. I. P. Shilov
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  2. V. D. Rumyantseva
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  3. A. V. Ivanov
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  4. Yu. V. Alekseev
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  5. A. S. Gorshkova
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  6. M. V. Ryabov
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  7. A. M. Kovaleva
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  8. M. I. Kovalev
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Corresponding author

Correspondence to I. P. Shilov.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

COMPLIANCE WITH ETHICAL STANDARDS

All patients voluntarily participated in the study in accordance with current ethical standards. (Research protocol no. 4/2020 dated February 5, 2020 was approved at the departmental conference of the Department of Obstetrics and Gynecology no. 1 of the Sechenov First Moscow State Medical University).

Work with laboratory animals (mice) was carried out in accordance with the ethical aspects of experimental research (European Concept for the Protection of Vertebrate Animals, Strasbourg, March 18, 1986)

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Translated by A. Ivanov

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Shilov, I.P., Rumyantseva, V.D., Ivanov, A.V. et al. Prospects for Infrared Luminescent Diagnostics of Superficially Located Neoplasms Using Ytterbium Porphyrin Complexes. J. Commun. Technol. Electron. 68, 474–480 (2023). https://doi.org/10.1134/S1064226923030130

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  • DOI: https://doi.org/10.1134/S1064226923030130

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