Abstract
We developed a pilot version of a laser-fiber fluorimeter for luminescence diagnostics of skin and mucous membrane cancers, operating in the near-IR spectral range (9–1100 nm). The main components of the device are considered: a compact semiconductor source of laser radiation, operating at a wavelength of 405 nm; a highly sensitive optoelectronic unit; a laptop with a developed program; and a high-aperture fiber optic probe (numerical aperture up to 0.32). The device, working in conjunction with a pharmaceutical composition of the Fluroscan type based on dipotassium salt of the ytterbium complex 2,4-di(α-methoxyethyl)deuteroporphyrin IX, ensures achievement of high values of the luminescence diagnostic contrast index of neoplasm/normal tissue (up to 50 units).
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ACKNOWLEDGMENTS
The authors are grateful to Yu.V. Alekseev and M.V. Ryabov, colleagues from the Laser Medicine medical center, for testing the developed laser-fiber fluorimeter on volunteer patients with basal cell skin cancer (superficial form).
Funding
The work was supported as part of a state task (project no. 0030-2019-0009).
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.
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Translated by O. Zhukova
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Shilov, I.P., Danielyan, G.L., Marechek, S.V. et al. Development of a Laser-Fiber Fluorimeter for IR Luminescence Cancer Diagnosis. J. Commun. Technol. Electron. 67, 463–469 (2022). https://doi.org/10.1134/S106422692204009X
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DOI: https://doi.org/10.1134/S106422692204009X