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Activation of Nanocomposite Liposomal Capsules in a Conductive Water Medium by Ultra-Short Electric Exposure

  • APPLICATIONS OF RADIOTECHNOLOGY AND ELECTRONICS IN BIOLOGY AND MEDICINE
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Abstract

In a system that simulates aquatic biological media, the possibility of activating nanocomposite liposomal capsules (NLCs) containing spherical electrically conductive nanoparticles on the outer and inner surfaces of the liposomal membrane, using an external ultrashort electric action, has been shown. The decapsulation effect was registrated by fluorimetry methods. The key role of conducting nanoparticles in increasing the sensitivity of NLCs to external ultrashort electrical impact is shown. A theoretical model of nonthermal interaction of NLCs with ultrashort electric pulses is constructed, within the frame of which an expression is obtained for the critical value of the electric field strength, which determines the threshold for the appearance of the decapsulation effect in a conducting medium. The described mechanism of decapsulation explains the selective nature of ultrashort pulsed electrical impact on the NLCs.

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Funding

This study was carried out as a part of state assignment (number AAAA-A19-119041590070-1) and with partial financial support from the Russian Foundation for Basic Research (project No. 18-29-02080).

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Authors and Affiliations

  1. Kotelnikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences, 125009, Moscow, Russia

    Yu. V. Gulyaev, V. A. Cherepenin, I. V. Taranov, V. A. Vdovin & G. B. Khomutov

  2. Moscow State University, 119992, Moscow, Russia

    G. B. Khomutov

Authors
  1. Yu. V. Gulyaev
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  2. V. A. Cherepenin
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  3. I. V. Taranov
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  4. V. A. Vdovin
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  5. G. B. Khomutov
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Correspondence to I. V. Taranov.

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Gulyaev, Y.V., Cherepenin, V.A., Taranov, I.V. et al. Activation of Nanocomposite Liposomal Capsules in a Conductive Water Medium by Ultra-Short Electric Exposure. J. Commun. Technol. Electron. 66, 88–95 (2021). https://doi.org/10.1134/S1064226921010022

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  • DOI: https://doi.org/10.1134/S1064226921010022

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