Abstract
A method for the preparation of samples from a biological material for the detection of upconversion nanoparticles (UNPs) contained in it is proposed on the basis of confocal microscopy techniques. The method was tested by monitoring the natural excretion of an injected colloidal solution of YVO4:Yb, Er nanoparticles with sizes from 10 to 700 nm (0.2 mL, containing 15 mg UNPs and with a dosage of 600 mg/kg) into the body of Helix lucorum. The experiments showed that the animal excreted the nanoparticles from the body in a natural way within 3 days, while the excretion rate decreased over time. The sensitivity threshold in the experiments was one nanoparticle per 1 µL.
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Funding
The synthesis of oxide UNPs was supported by a grant from the Ministry of Education and Science of the Russian Federation under agreement no. 075-15-2021-623 with Federal Research Center Kazan Scientific Center, Russian Academy of Sciences. Spectroscopic measurements were supported by the Russian Foundation for Basic Research within the frameworks of grants nos. 19-02-00569 A and 20-52-04018 Bel_mol_ai no. 20-02-00545 A. Animal experiments were carried out with financial support from the PRIORITET-2030 Strategic Academic Leadership Program for Kazan Federal University.
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Shmelev, A.G., Nikiforov, V.G., Zharkov, D.K. et al. Monitoring of the Natural Excretion of YVO4:Yb, Er Upconversion Nanoparticles from a Land Snail. Tech. Phys. 67, 283–288 (2022). https://doi.org/10.1134/S1063784222050097
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DOI: https://doi.org/10.1134/S1063784222050097