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Development of an NMR Relaxometer for Determining Magnetization Dynamics of Water Protons in Living Tissues and Its Use for Evaluating Age-Related Changes

  • PHYSICS FOR SCIENCES OF LIFE
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Abstract

A desktop NMR relaxometer was created, which allows determining spin–spin relaxation times of water protons in living tissues. Spin relaxation times of protons of water reflect changes in the mean number of paramagnetic centers, since the presence of these centers increases the magnetization recovery rate of water protons in living tissues tens of times. In particular, this method allowed observing age-related changes (sarcopenia) related to substitution of connective tissue for muscle fibers. Relaxometers of this type are comfortable to use and are promising devices for analysis and diagnostics of changes and disorders of metabolic processes.

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REFERENCES

  1. A. Abragam, The Principles of Nuclear Magnetism (Clarendon, 1961).

    Google Scholar 

  2. V. I. Chizhik et al., Magnetic Resonance and Its Applications (Springer, 2014).

    Book  Google Scholar 

  3. Yu. I. Neronov, Magnetic Resonance in Tomography and Spectral Studies of Living Tissue (Univ. ITMO, St. Petersburg, 2007).

    Google Scholar 

  4. V. K. Ivanov, Yu. I. Neronov, and V. A. Ivanov, Nauchno-Tekh. Vestn. S.-Peterb. Gos. Inst. Tochn. Mekh. Opt., No. 3, 201 (2001).

  5. Yu. I. Neronov and V. K. Ivanov, Nauchn. Priborostr. 16 (2), 105 (2006).

    Google Scholar 

  6. Yu. I. Neronov, Izv. Vyssh. Uchebn. Zaved., Priborostr. 51 (10), 47 (2008).

    Google Scholar 

  7. L. A. Tyutin and Yu. I. Neronov, RF Patent No. 2063702 (1996).

  8. Y. I. Neronov and A. N. Seregin, Meas. Tech. 54, 103 (2011).

    Article  Google Scholar 

  9. Y. I. Neronov and A. N. Seregin, Meas. Tech. 53, 926 (2010).

    Article  Google Scholar 

  10. Yu. I. Neronov and V. S. Aleksandrov, JETP Lett. 94, 418 (2011).

    Article  ADS  Google Scholar 

  11. Yu. I. Neronov and N. N. Seregin, Metrologia 51, 54 (2014).

    Article  ADS  Google Scholar 

  12. D. D. Kosenkov, Y. I. Neronov, A. N. Zolotov, and N. N. Seregin, in Proc. 15th Int. School-Conf. “Magnetic Resonance and Its Applications,” St. Petersburg, Russia, 2018, p. 77.

  13. A. N. Zolotov, Y. I. Neronov, and D. D. Kosenkov, in Proc. 15th Int. School-Conf. “Magnetic Resonance and Its Applications,” St. Petersburg, Russia, 2018, p. 130.

  14. Yu. I. Neronov, A. N. Zolotov, D. D. Kosenkov, and N. N. Seregin, in Open Science 2.0: Collection of Scientific Articles (Open Science, Raleigh, 2018), Vol. 4, pp. 118–123.

    Google Scholar 

  15. V. V. Povoroznyuk and N. V. Grigorieva, Menopause and Musculoskeletal System (Kniga Plyus, Kyiv, 2004).

    Google Scholar 

  16. V. M. Undritsov, I. M. Undritsov, and L. D. Serova, in Gerontology Manual, Ed. by V. N. Shabalin (Tsitadel’ Treid, Moscow, 2005), pp. 486–499.

  17. V. M. Undritsov, I. M. Undritsov, and L. D. Serova, Fizkul’t. Profil., Lech. Reabil., No. 4, 7 (2009).

  18. T. Lang, T. Streeper, P. Cawthon, et al., Osteoporosis Int. 21, 543 (2010).

    Article  Google Scholar 

  19. L. A. Burton and D. Sumukadas, Clin. Interventions Aging 5, 217 (2010).

    Google Scholar 

  20. A. J. Cruz-Jentoft, J. P. Baeyens, J. M. Bauer, et al., Age Ageing 39, 412 (2010).

    Article  Google Scholar 

  21. Wm. C. Chumlea, M. Cesari, W. J. Evans, et al., J. Nutr., Health Aging 15, 450 (2011).

    Article  Google Scholar 

  22. S. T. Artur and I. D. Colley, Int. J. Biol. Sci. 8, 731 (2012).

    Article  Google Scholar 

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Authors and Affiliations

  1. Mendeleev Institute for Metrology, 190005, St. Petersburg, Russia

    Yu. I. Neronov & D. D. Kosenkov

  2. ITMO University, 193101, St. Petersburg, Russia

    Yu. I. Neronov & D. D. Kosenkov

Authors
  1. Yu. I. Neronov
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  2. D. D. Kosenkov
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Correspondence to Yu. I. Neronov.

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Translated by S. Efimov

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Neronov, Y.I., Kosenkov, D.D. Development of an NMR Relaxometer for Determining Magnetization Dynamics of Water Protons in Living Tissues and Its Use for Evaluating Age-Related Changes. Tech. Phys. 64, 1055–1059 (2019). https://doi.org/10.1134/S106378421907017X

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  • DOI: https://doi.org/10.1134/S106378421907017X

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