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Role of the Matrix Effect in Analysis of Biological Objects Using Mass Spectrometry with Inductively Coupled Plasma

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Abstract

An attempt at eliminating the nonspectral matrix effect leading to suppression of the analytic signal intensity at instrument output has been made using an Agilent-7700 mass spectrometer with inductively coupled plasma with a quadrupole analyzer for several elements in blood and urine. It is shown that acid and salt compositions, as well as organic substances in the composition of the sample itself, play a decisive role in the emergence of the nonspectral matrix effect. The role of acid, salt, and organic compositions of the entire blood matrix and urine in underrating the results of determination of several elements has been estimated. It has also been shown that the internal standard must be chosen proceeding from the closeness of its first ionization potential to the first ionization potential of the element being determined. The contributions of nonspectral matrix effects to the distortion of the results of analysis of biological liquids have been analyzed and estimated. It has been found that the dependence of the matrix effect on salts in the acidic matrix and on the operating regime of the instrument is additive.

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REFERENCES

  1. A. A. Pupyshev and V. T. Surikov, Inductively Coupled Plasma Mass Spectrometry. Ion Production (Ural. Otd. Ross. Akad. Nauk, Yekaterinburg, 2006).

    Google Scholar 

  2. Agilent 7700 ICP-MS Specifications (Agilent Technologies, 2012).

  3. P. J. Parsons and F. Barbosa, Spectrochim. Acta B 62, 992 (2007).

    Article  ADS  Google Scholar 

  4. D. V. Yaroshenko and L. A. Kartsova, J. Anal. Chem. 69, 311 (2014).

    Article  Google Scholar 

  5. R. Xu, L. Fan, M. Rieser, and T. El-Shourbagy, J. Pharm. Biomed. 44, 342 (2007).

    Article  Google Scholar 

  6. A. Ciric, H. Prosen, M. Jelikic-Stankov, and P. Durdevic, Talanta 99, 780 (2012).

    Article  Google Scholar 

  7. R. King, R. Bonfiglio, C. Fernandez-Metzler, C. Miller-Stein, and T. Olah, J. Am. Soc. Mass Spectrom. 11, 942 (2000).

    Article  Google Scholar 

  8. R. Dams, M. Huestis, W. Lambert, and C. Murphy, J. Am. Soc. Mass Spectrom. 14, 1290 (2003).

    Article  Google Scholar 

  9. I. I. Stewart and J. W. Olesik, J. Anal. At. Spectrom. 13, 1313 (1998).

    Article  Google Scholar 

  10. J.-L. Todoli and J.-M. Mermet, Spectrochim. Acta B 54, 895 (1999).

    Article  ADS  Google Scholar 

  11. M. A. Kartasheva, V. G. Borovitskii, and S. Yu. Dubnikov, RF Patent No. 2039970 (1995).

  12. T. W. May and R. H. Wiedmeyer, At. Spectrosc. 19, 150 (1998).

  13. T. K. Nurubeyli, Z. K. Nurubeyli, K. Z. Nuriyev, and K. B. Gurbanov, Tech. Phys. 62, 305 (2017).

    Article  Google Scholar 

  14. G. I. Ramendik, E. V. Fatyushina, A. I. Stepanov, and V. S. Sevast’yanov, J. Anal. Chem. 56, 500 (2001).

    Article  Google Scholar 

  15. A. M. Gashimov, K. Z. Nuriev, S. Manuchar, K. B. Gurbanov, and Z. K. Nurubeili, Surf. Eng. Appl. Electrochem. 44, 159 (2008).

    Article  Google Scholar 

  16. Z. K. Nurubeili, K. Z. Nuriev, and G. M. Kerimov, Surf. Eng. Appl. Electrochem. 49, 331 (2013).

    Article  Google Scholar 

  17. A. F. Pupyshev and E. V. Semenova, Anal. Kontrol’ 4, 120 (2000).

    Google Scholar 

  18. J. Emsley, The Elements (Clarendon, 1998).

  19. C. Tanaselia, T. Frentiu, M. Ursu, M. Vlad, M. Chintoanu, E. Cordos, L. David, M. Paul, and D. Gomoiescu, Optoelectron. Adv. Mater. 2, 99 (2008).

    Google Scholar 

  20. D. R. Lide and B. Raton, CRC Handbook of Chemistry and Physics, 89th ed. (CRC, 2008).

    Google Scholar 

  21. S. Awad, S. P. Allison, and D. N. Lobo, Clin. Nutr. 27, 179 (2008).

    Article  Google Scholar 

  22. A. V. Skal’nyi, Chemical Elements in Human Physiology and Ecology (Oniks 21 Vek, Moscow, 2004).

  23. V. K. Karandashev, A. Yu. Leykin, and K. Z. Zhernokleeva, J. Anal. Chem. 69, 22 (2014).

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Physics, National Academy of Sciences of Azerbaijan, Az-1143, Baku, Azerbaijan

    T. K. Nurubeyli, K. Z. Nuriyev, Z. K. Nurubeyli & K. B. Gurbanov

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  1. T. K. Nurubeyli
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  2. K. Z. Nuriyev
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  3. Z. K. Nurubeyli
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  4. K. B. Gurbanov
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Correspondence to T. K. Nurubeyli.

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Translated by N. Wadhwa

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Nurubeyli, T.K., Nuriyev, K.Z., Nurubeyli, Z.K. et al. Role of the Matrix Effect in Analysis of Biological Objects Using Mass Spectrometry with Inductively Coupled Plasma. Tech. Phys. 64, 909–915 (2019). https://doi.org/10.1134/S1063784219060148

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  • DOI: https://doi.org/10.1134/S1063784219060148

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