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Physicochemical Properties and Structure of the Bone Matrix in Simulated Tuberculous Osteitis

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Abstract

The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we revealed that tuberculous osteitis causes fine disintegration of the bone matrix due to an increase in nonstoichiometric hydroxyapatite, formation of amorphous calcium phosphates, and a decrease of the organic phase, which is accompanied by embrittlement of the bone matrix. Excessive growth of carbonate-hydroxyapatite crystals of a mixed AB substitution type leads to excessive osteogenesis, accompanied by the uncontrolled growth of bone trabeculae. The presence of “liming” regions in the crystal lattice of hydroxyapatite increases the “binding” properties of the bone matrix in which mycobacteria are immobilized and removed in the composition of detritus.

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Authors and Affiliations

  1. Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, 220079, Minsk, Belarus

    V. K. Krut’ko, O. N. Musskaya & A. I. Kulak

  2. St. Petersburg Research Institute of Phthisiopulmonology, 191036, St. Petersburg, Russia

    V. V. Kazbanov, A. A. Gaidash & M. S. Serdobintsev

  3. Republican Scientific and Practical Center for Pediatric Surgery, 220013, Minsk, Belarus

    V. V. Kazbanov & A. A. Gaidash

  4. Physicotechnical Institute, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    N. M. Chekan

  5. Research Institute of Physical and Chemical Problems, 220030, Minsk, Belarus

    K. V. Skrotskaya

Authors
  1. V. K. Krut’ko
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  2. V. V. Kazbanov
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  3. O. N. Musskaya
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  4. A. A. Gaidash
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  5. A. I. Kulak
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  6. N. M. Chekan
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  7. M. S. Serdobintsev
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  8. K. V. Skrotskaya
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Corresponding author

Correspondence to O. N. Musskaya.

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Translated by O. Zhukova

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Krut’ko, V.K., Kazbanov, V.V., Musskaya, O.N. et al. Physicochemical Properties and Structure of the Bone Matrix in Simulated Tuberculous Osteitis. Tech. Phys. 64, 121–126 (2019). https://doi.org/10.1134/S1063784219010183

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  • DOI: https://doi.org/10.1134/S1063784219010183

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