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Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica

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Abstract

Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe3O4 and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.

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ACKNOWLEDGMENTS

S.V. Shmakov, V.V. Klimenko, and S.V. Konyakhin are grateful for the financial support of the Skolkovo Foundation (the Grant Agreement for the Russian Educational and Scientific Organization no. 7 of December 19, 2017) and the Skolkovo Institute of Science and Technology (General Agreement on Research Activities no. 3663-MRA of December 25, 2017).

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Authors and Affiliations

  1. St. Petersburg National Research Academic University, Russian Academy of Sciences, 194021, St. Petersburg, Russia

    S. V. Shmakov, V. V. Klimenko & S. V. Konyakhin

  2. Ioffe Institute, Russian Academy of Sciences, 194021, St. Petersburg, Russia

    D. A. Eurov, D. A. Kurdyukov & V. G. Golubev

Authors
  1. S. V. Shmakov
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  2. V. V. Klimenko
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  3. S. V. Konyakhin
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  4. D. A. Eurov
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  5. D. A. Kurdyukov
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  6. V. G. Golubev
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Correspondence to S. V. Shmakov.

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Translated by O. Zhukova

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Shmakov, S.V., Klimenko, V.V., Konyakhin, S.V. et al. Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica. Tech. Phys. 63, 1316–1322 (2018). https://doi.org/10.1134/S1063784218090190

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  • DOI: https://doi.org/10.1134/S1063784218090190

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