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Monitoring of propofol and its metabolite during total intravenous anesthesia

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Abstract

Intravenous hypnotic propofol and its metabolite are detected in real time during total intravenous anesthesia by an electron ionization mass spectrometer. The mass spectrometer is connected directly to the breathing circuit of an apparatus for inhalational anesthesia. Ratios between the propofol concentrations in expired air and blood serum are measured. It is concluded that real-time noninvasive monitoring of the propofol concentration in blood using electron ionization mass spectrometry is feasible.

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Authors and Affiliations

  1. Ioffe Physical Technical Institute, Russian Academy of Sciences, Politekhnicheskaya ul. 16, St. Petersburg, 194021, Russia

    A. Yu. Elizarov & T. D. Ershov

  2. Kirov Military Medical Academy, ul. Akademika Lebedeva 6, St. Petersburg, 194044, Russia

    A. I. Levshankov

Authors
  1. A. Yu. Elizarov
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  2. T. D. Ershov
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  3. A. I. Levshankov
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Corresponding author

Correspondence to A. Yu. Elizarov.

Additional information

Original Russian Text © A.Yu. Elizarov, T.D. Ershov, A.I. Levshankov, 2011, published in Zhurnal Tekhnicheskoi Fiziki, 2011, Vol. 81, No. 12, pp. 110–113.

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Elizarov, A.Y., Ershov, T.D. & Levshankov, A.I. Monitoring of propofol and its metabolite during total intravenous anesthesia. Tech. Phys. 56, 1807–1810 (2011). https://doi.org/10.1134/S1063784211120024

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  • DOI: https://doi.org/10.1134/S1063784211120024

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