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Structure of amyloid aggregates of lysozyme from small-angle X-ray scattering data

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Abstract

The structure of filament amyloid aggregates of hen egg white lysozyme in water has been investigated by the small-angle X-ray scattering method. The experimental data are described by different cylindrical models, among which the best agreement is reached with the long helix model. A comparison of the results with the small-angle neutron scattering data reveals the influence of the heavy component of the solvent (a H2O/D2O mixture) on the structure of the filaments.

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, ul. Joliot-Curie 6, Dubna, Moscow oblast, 141980, Russia

    V. I. Petrenko, M. V. Avdeev & V. L. Aksenov

  2. Taras Shevchenko National University of Kyiv, ul. Volodymyrska 60, Kyiv, 01601, Ukraine

    V. I. Petrenko & L. A. Bulavin

  3. Helmholtz-Zentrum Geesthacht, Max-Planck-Straße 1, Geesthacht, 21502, Germany

    V. M. Garamus

  4. Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, Košice, 040 01, Slovakia

    M. Kubovcikova, Z. Gažová, K. Šipošová & P. Kopcansky

  5. Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, 29-33 Konkoly-Thege M. Street, Budapest, Hungary

    L. Almásy

  6. Konstantinov Petersburg Nuclear Physics Institute, National Research Centre “Kurchatov Institute,” Orlova Roshcha, Gatchina, Leningrad oblast, 188300, Russia

    V. L. Aksenov

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  1. V. I. Petrenko
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  2. M. V. Avdeev
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  3. V. M. Garamus
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  4. M. Kubovcikova
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  5. Z. Gažová
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  6. K. Šipošová
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  7. L. A. Bulavin
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  10. P. Kopcansky
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Correspondence to V. I. Petrenko.

Additional information

Original Russian Text © V.I. Petrenko, M.V. Avdeev, V.M. Garamus, M. Kubovcikova, Z. Gažová, K. Šipošová, L.A. Bulavin, L. Almásy, V.L. Aksenov, P. Kopcansky, 2014, published in Fizika Tverdogo Tela, 2014, Vol. 56, No. 1, pp. 129–133.

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Petrenko, V.I., Avdeev, M.V., Garamus, V.M. et al. Structure of amyloid aggregates of lysozyme from small-angle X-ray scattering data. Phys. Solid State 56, 129–133 (2014). https://doi.org/10.1134/S1063783414010284

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