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Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10–30 MeV for isotope production

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Abstract

A survey of commercial cyclotrons for production of medical and industrial isotopes is presented. Compact isochronous cyclotrons which accelerate negative hydrogen ions in the energy range 10–30 MeV have been widely used over the last 25 years for production of medical isotopes and other applications. Different cyclotron models for the energy range 10–12 MeV with moderate beam intensity are used for production of 11C, 13N, 15O, and 18F isotopes widely applied in positron emission tomography. Commercial cyclotrons with high beam intensity are available on the market for production of most medical and industrial isotopes. In this work, the physical and technical parameters of different models are compared. Possibilities of improving performance and increasing intensity of H− beams up to 2–3 mA are discussed.

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References

  1. H. Fitze et al., “Developments at PSI (Including New RF Cavity),” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 67–71.

  2. G. Dutto et al., “TRIUMF High Intensity Cyclotron Development for ISAC,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 82–86.

  3. Y. Jongen et al., “CYCLONE18+. Commercial Cyclotrons — Manufactures,” in Proc. of the XV Int. Conf. on Cycl. and their Appl. (GANIL, France, 1998), p. 793.

    Google Scholar 

  4. W. Kleeven et al., “The Self-Extracting Cyclotron,” in Proc. of the XVI Int. Conf. on Cycl. and their Appl. (NSCL MSU, USA, 2001), pp. 69–73.

    Google Scholar 

  5. Y. Jongen et al., “New Cyclotron Developments at IBA,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 110–114.

  6. R. Baartman, “Intensity Limitations in Compact H− Cyclotrons,” in Proc. of the XIV Int. Conf. on Cycl. and their Appl. (Cape Town, South Africa, 1995), pp. 440–445.

  7. T. Kuo et al., “On the Development of 2mA RF H− Beams for Compact Cyclotrons,” in Proc. of the XIV Int. Conf. on Cycl. and their Appl. (Cape Town, South Africa, 1995), pp. 177–180.

  8. T. Kuo et al., “Injection Study for High Current H− Cyclotrons,” in Proc. of the XV Int. Conf. on Cycl. and their Appl. (GANIL, France, 1998), pp. 381–384.

    Google Scholar 

  9. G-J. Beyer, “Future Requirements Concerning Medical Isotope Production with Accelerators,” Presentation at the ECPM 2005 (Nice, France, 2005).

  10. V. Bechtold et al., “Modern Gas-Target Technology for the Production of High Quality Radiopharmaceuticals,” in Proc. of the XII Int. Conf. on Cycl. and Their Appl. (Berlin, Germany, 1989), pp. 519–522.

  11. S. Strangis et al., “The Cyclotron Radioisotopes Production Facility of the Argentina Atomic Energy Commission (CNEA),” in Proc. of the XVI Int. Conf. on Cycl. and their Appl. (NSCL MSU, USA, 2001), pp. 142–144.

    Google Scholar 

  12. Y. Jongen et al., IBA Private Commun.; www.appliedradiology.com; in Proc. of 5th Intern. Conf. on Isotopes, Brussels, Belgium, April 25–29, 2005.

  13. Eckert and Ziegler Company, BEBIG Izoseed I-125, www.ezag.de (Germany, Berlin, 2005).

  14. J. Conradie et al., “Cyclotrons at iThemba LABS,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 105–109.

  15. N. Krasnov, “Radioizotope Production,” in ZAO Tsiklotron (FEI, Obninsk, 2003), p. 8 [in Russian].

    Google Scholar 

  16. V. Glukhih et al., “Applied Cyclotrons Developed and Constructed in NIIEPHA,” in Proc. of the XII Int. Conf. on Cycl. and Their Appl. (Berlin, Germany, 1989), pp. 167–169.

  17. Cyclotron U-120. Laboratory of Production of Radioactive Materials (PRM) of NIIYaF Tomsk Politechnical University (Rossiya, Tomsk, 2005), p. 6 [in Russian]; www.npi.tpu.ru.

  18. E. Ts. Choinzonov et al., “20 Years Experience of Neutron Therapy at Cyclotron U-120,” in Proc. of 3rd Symp. of Oncologists and Radiologists of Independent States Union No. 83451826 (Belorussiya, Minsk, 2004), pp. 344–345.

  19. Yu. G. Alenitskii et al., “Isochronous Cyclotron U-120M,” in Proc. of 5th All-Union Conf. on Charged Particles Accelerators (Nauka, Moscow, 1977), Vol. 1, pp. 154–159.

    Google Scholar 

  20. J. Shtursa et al., Production of Radio-Nuclides for Nuclear Medicine on the Isochronous Cyclotron U-120 (Rzezh, Czech Rep., 1985), p. 6; http://uc.jinr.ru/SummerSchool/shtursa.html.

  21. W. Kleeven, “The Self-Extracting Cyclotron Project,” in Proc. of XVI Int. Conf. on Cycl. and their Appl. (NSCL MSU, USA, 2001), p. 41.

    Google Scholar 

  22. G. Hendry et al., “Design and Performance of a Compact H− Cyclotron,” in Proc. of the IX Int. Conf. on Cyclotrons (GANIL, France, 1981), pp. 125–128.

    Google Scholar 

  23. J. Modeer et al., “MC32NI. Commercial Cyclotrons — Manufactures,” in Proc. of the XIII Int. Conf. on Cycl. and their Appl. (Vancouver, Canada, 1992), p. 860.

    Google Scholar 

  24. K. Ehler, “Design Consideration for High Intensity Negative Ion Source,” Nucl. Instrum. Methods Phys. Res. 32, 811 (1965).

    Google Scholar 

  25. T. Kuo et al., “Recent Development of Internal H−/D+ Source for Compact Cyclotrons,” in Proc. of the XIII Int. Conf. on Cycl. and their Appl. (Vancouver, Canada, 1992), pp. 352–356.

  26. K. Abbas et al., “Use of the Scanditronix MC40 Cyclotron of the JRC (EC) for FDG Production in Compliance with the European GMP,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 25–27.

  27. J. Chai et al., “Development and Status Report of Medical Cyclotron at KIRAMS,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 87–89.

  28. V. Belov et al., “Medical Compact Cyclotron SS-18/9,” in Proc. of 11th Intern. Conf. on Charged Particle Accel. Applied in Industry and Medicine ICAA 05 (St. Petersburg, 2005), pp. 237–239.

  29. P. Bogdanov et al., “Compact Cyclotron SS-12 for PET Centers,” in Proc. of 11th Intern. Conf. on Charged Particle Accel. Applied in Industry and Medicine ICAA’05 (St. Petersburg, 2005), pp. 249–252.

  30. Yu. Alenitsky et al., “Cyclotron for Production of Positron Emission Isotopes in DLNP JINR,” in Proc. of 7th Intern. Sarantcev Seminar (Alushta, JINR, 2007), p. 5.

  31. B. Alword, “Radioisotope Delivery System RDS-112. Commercial Cycl.—Manufactures,” in Proc. of the XIII Int. Conf. on Cycl. and their Appl. (Vancouver, Canada, 1992), p. 865.

  32. B. Alword, Radioisotope Delivery System RDS-111. Technical Description (CTI, Knoxville, Tennessee, USA, 1995), p. 20.

    Google Scholar 

  33. S. Zaremba et al., “C10 Cyclotron. Commercial Cyclotrons-Manufactures,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), p. 605.

  34. Y. Jongen et al., ìA New Design of Truly Selfshielding Baby-Cyclotrons for Positron Emitter Production,” in Proc. of the XII Int. Conf. on Cycl. and Their Appl. (Berlin, Germany, 1989), pp. 164–166.

  35. Y. Jongen et al., “CYCLONE18/9 Cyclotron. Commercial Cyclotrons—Manufactures,” in Proc. of the XIII Int. Conf. on Cycl. and their Appl. (Vancouver, Canada, 1992), p. 853.

  36. R. Johnson et al., “Cyclotron TR13. Commercial Cyclotrons — Manufactures,” in Proc. of the XIV Int. Conf. on Cycl. and their Appl. (Cape Town, South Africa, 1995), p. 772.

  37. K. Erdman et al., “Initial Operation of the Sherbrooke EBCO 19 MeV Cyclotron,” in Proc. of the XV Int. Conf. on Cycl. and their Appl. (GANIL, France, 1998), pp. 327–330.

    Google Scholar 

  38. S. Sytchevsky et al., “KOMPOT3D Field Simulations for Cyclotron Magnet Systems,” in Proc. of The XIII Int. Conf. on Charged Particle Accel. Applied in Medicine and Industry ICAA’05 (Petersburg, 2005), pp. 211–214.

  39. Y. Jongen et al., “PET Cyclotron, CYCLONE18/9.IBA,” (Belgium, 2006); www.iba.be.

  40. B. Milton, “Commercial Compact Cyclotrons in the’ 90s,” in Proc. of the XIV Int. Conf. on Cycl. and their Appl. (Cape Town, South Africa, 1995), pp. 99–106.

  41. A. Papash et al., “On Commercial Cyclotron of Intense Proton Beam of 30 MeV Energy Range,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 438–440.

  42. B. Gikal et al., “Accelerating Complex ITs100 for Making of Scientific Applied Investigations,” Preprint OIYaI R9-2007-20 (Dubna, 2007).

  43. G. McKinney et al., “Computer Code MCNPX Overview,” LA-UR-06-6206 (FNAL, USA, 2006); www.mcnpx.lanl.gov.

  44. M. Abs et al., “Angular Dose Distribution Around C18/9 Cyclotron,” IBA Intern. Rep. (2002), p. 12.

  45. L. Root et al., “TR13 Magnet Design,” TRIUMF Design Note TRI-DN-93-14 (TRIUMPH, Canada, 1993), p. 54.

  46. M. Dehnel, “An Industrial Cyclotron Ion Source and Injection System,” in Proc. of the XVII Int. Conf. on Cycl. and Their Appl. (Japan, Tokyo, 2004), pp. 293–295.

  47. T. Kuo et al., “Development of a 15 mA DC H− Multi-CUSP Source for Cyclotron,” in Proc. of the XIV Int. Conf. on Cycl. and their Appl. (Cape Town, South Africa, 1995), pp. 420–423.

  48. R. Laxdal et al. “Beam Measurements on a Small Cyclotron,” in Proc. of the 4th European Particle Accel. Conf. EPAC-2004 (England, London, 2004), pp. 545–548.

  49. A. Papash et al. “Compact 9 MeV Deuteron Cyclotron with Pulsed Beam,” in Proc. of the XVI Int. Conf. on Cycl. and their Appl. (NSCL MSU, USA, 2001), pp. 383–386.

    Google Scholar 

  50. A. Papash et al. “TR13 Cyclotron Extraction Studies,” TRIUMF Design Note TRI-DN-93-5 (TRIUMF, Canada, 1993), p. 38.

    Google Scholar 

  51. Y. Jongen et al. “Construction of the Louvain-La-Neuve 30 MeV-500 μA H− Cyclotron,” in Proc. of the XI Int. Conf. on Cycl. and their Appl. (Tokyo, Japan, 1986), pp. 234–239.

  52. J. Bol et al. “High Intensity H− Cyclotrons for Radioisotope Production,” in Proc. of the XII Int. Conf. on Cycl. and Their Appl. (Berlin, Germany, 1989), pp. 149–151.

  53. B. Milton et al. “A 30 MeV H− Cyclotron for Isotope Production,” in Proc. of the XII Int. Conf. on Cycl. and Their Appl. (Berlin, Germany, 1989), pp. 145–148.

  54. M. Dehnel, “Industrial Multi-CUSP Sources of H− Ions,” (Vancouver, Canada, 2006), http://www.d-pace.com

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  1. Joint Institute for Nuclear Research, Dubna, Russia

    A. I. Papash & Yu. G. Alenitsky

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Original Russian Text © A.I. Papash, Yu.G. Alenitsky, 2008, published in Fizika Elementarnykh Chastits i Atomnogo Yadra, 2008, Vol. 39, No. 4.

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Papash, A.I., Alenitsky, Y.G. Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10–30 MeV for isotope production. Phys. Part. Nuclei 39, 597–631 (2008). https://doi.org/10.1134/S1063779608040060

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