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Development of Equipment for Simultaneous Hyperthermia and Radiation Therapy of Malignant Neoplasms

  • MEDICAL PHYSICS AND BIOPHYSICS
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Abstract

A series of applicators has been developed on the basis of phased array (PA) for electromagnetic high-frequency hyperthermia and simultaneous radiation therapy of tumors characterized by high transparency to gamma radiation. The resistance of the main material of the microstrip emitter and its array against ionizing radiation has been studied. A possible seven dimensions of PA applicators operating at a frequency of 434 MHz have been considered. The distribution of the squared electric component of the electromagnetic field emitted by an applicator in the plane of the applicator aperture, the SAR (specific absorption rate) has been measured. The experimental results of the SAR distribution in the plane of the applicator aperture from single modules for electromagnetic exciting fields differing in phases are presented. The main parameters of the Quality Standard in oncological hyperthermia have been considered, which should be achieved in the treatment of oncological patients with the specific list of nosological forms of neoplasms.

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REFERENCES

  1. N. N. Alexandrov, N. Y. Savchenko, and S. Z. Fradkin, Application of Hyperthermia and Hyperglycemia in Treatment of Malignanttumors (Meditsina, Moscow, 1980) [in Russian].

    Google Scholar 

  2. S. B. Field and J. W. Hand, An Introduction to the Practical Aspects of Clinical Hyperthermia (Taylor and Francis, London, 1990).

    Google Scholar 

  3. J. D. van der Zee, D. Gonzales-Gonzales, and G. van Rhoon, Lancet 335 (9210), 1119 (2000).

    Article  Google Scholar 

  4. G. C. van Rhoon, P. J. M. Rietveld, and J. van der Zee, Int. J. Hyperthermia 14, 13 (1998).

    Article  Google Scholar 

  5. M. K. Gopal and T. C. Cetas, IEEE Trans. Microwave Theory Tech. 41, 431 (1993).

    Article  ADS  Google Scholar 

  6. P. R. Staufer, F. Rosseto, and M. Leoncini, IEEE Trans. Biomed. Eng. 45, 605 (1998).

    Article  Google Scholar 

  7. R. J. Myerson, W. L. Straube, and M. Taylor, in Proceedings of the 9th International Congress of Hyperthermic Oncology ICHO, 2004, p. 80.

  8. R. J. Myerson, W. L. Straube, and E. G. Moros, in Proceedings of the 9th International Congress of Hyperthermic Oncology ICHO, 2004, p. 90.

  9. E. A. Gelvich, in Proceedings of the 17th Annual Meeting of the European Society for Hyperthermic Oncology ESHO, 1998, p. 23.

  10. A. N. Averkin, A. A. Vainson, E. A. Gel’vich, G. E. Gorlachev, A. A. Zvantsev, V. A. Klimanov, V. V. Kosterev, E. A. Kramer-Ageev, V. N. Mazokhin, V. V. Meshcherikova, O. A. Mishulina, N. N. Mogilenets, V. I. Sinyagovskii, and V. V. Smirnov, Yad. Fiz. Inzhin. 1, 241 (2010).

    Google Scholar 

  11. M. V. Prior, M. L. D. Lumori, and J. W. Hand, IEEE Trans. Biomed. Eng. 42, 694 (1995).

    Article  Google Scholar 

  12. M. K. Gopal, J. W. Hand, and M. L. D. Lumori, Int. J. Hypertherm. 8, 227 (1992).

    Article  Google Scholar 

  13. E. A. Gelvich, D. N. Kolmakov, and V. N. Mazokhin, COMAC-BME Hypertherm. Bull., No. 10, 66 (1992).

  14. E. A. Gelvich, V. N. Mazokhin, and I. I. Troshin, in Proceedings of the 2nd International Scientific Meeting on Microwave in Medicine (Rome, 1993), p. 71.

  15. E. A. Gelvich, V. N. Mazokhin, and S. L. Tkachev, in Proceedings of the 7th International Congress on Hyperthermia Oncology (Rome, 1996), p. 449.

  16. G. G. Lamaitre, J. D. P. van Dijk, and E. A. Gelvich, Int. J. Hypertherm. 12, 255 (1996).

    Article  Google Scholar 

  17. C. Marchal, P. Tekieli, and C. Niederst, in Proceedings of the 15th Annual Meeting of European Society for Hyperthermic Oncology ESHO (Oxford, 1995), p. 9.

  18. N. van Wieringen, E. A. Gelvich, and J. D. P. van Dijk, in Proceedings of the 18th Annual Meeting of the European Society for Hyperthermic Oncology ESHO (Rotterdam, 1999), p. 82.

  19. H. Meinke and F. W. Gundlach, Taschenbuch der Hochfrequenztechnik (Munich, Germany, 1956).

    Book  Google Scholar 

  20. E. A. Gelvich and V. N. Mazokhin, Int. J. Hypertherm. 16, 113 (2000).

    Article  Google Scholar 

  21. V. N. Mazokhin, D. N. Kolmakov, and N. A. Lucheyov, Int. J. Hypertherm. 15, 309 (1999).

    Article  Google Scholar 

  22. M. W. Dewhirst, T. L. Phillips, and T. V. Simulski, Int. J. Radiat. Oncol. Biol. Phys. 18, 1249 (1990).

    Article  Google Scholar 

  23. V. V. Kosterev, E. A. Kramer-Ageev, V. N. Mazokhin, G. C. van Rhoon, and J. Crezee, Int. J. Hypertherm. 31, 443 (2015).

    Article  Google Scholar 

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Funding

This work was supported by Rosatom, project EOTP-YaM-115.

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Authors and Affiliations

  1. National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409, Moscow, Russia

    V. V. Kosterev

  2. JSC NPP Istok, 141190, Fryazino, Russia

    V. N. Mazokhin

Authors
  1. V. V. Kosterev
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  2. V. N. Mazokhin
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Correspondence to V. V. Kosterev.

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The authors declare that they have no conflicts of interest.

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Translated by I. Moshkin

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Kosterev, V.V., Mazokhin, V.N. Development of Equipment for Simultaneous Hyperthermia and Radiation Therapy of Malignant Neoplasms. Phys. Atom. Nuclei 85, 1931–1942 (2022). https://doi.org/10.1134/S1063778822100283

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