Abstract
Gallstones with a zonal morphological structure have been studied using X-ray microtomography, X-ray diffraction analysis, Raman spectroscopy, and elemental analysis. Concrements have been investigated in vitro in the dried state; phases of cholesterol, bilirubin, calcium carbonate, and sodium and potassium chlorides are found in their composition. The analysis is performed within the development of tomographic methods, which can be used in future for intravital diagnostics of cholesterol cholelithiasis. The possibility of determining the phase composition of heterogeneous gallstones, based on the analysis of linear-absorption-coefficient distributions derived from X-ray monochromatic microtomography data, is demonstrated. The results of the tomographic analysis are in agreement with the data obtained using conventional direct methods for determining the phase and elemental composition of the objects under study.
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REFERENCES
G. Novacek, Wien. Med. Wochenschr. 156, 527 (2006).
H. Sun, H. Tang, S. Jiang, et al., World J. Gastroenterol. 15, 1886 (2009).
J. E. Everhart, M. Khare, M. Hill, et al., Gastroenterology 117, 632 (1999).
H. Völzke, S. E. Baumeister, D. Alte, et al., Digestion 71, 97 (2005).
J. Qin, T. Q. Han, J. Fei, et al., Zhonghua Yi Xue Za Zhi 85, 1966 (2005).
S. A. Abu-Eshy, A. A. Mahfouz, A. Badr, et al., East. Mediterr. Health J. 13, 794 (2007).
G. S. Stuart, J. H. Tang, S. F. Heartwell, et al., Contraception 76, 357 (2007).
D. J. Cirillo, R. B. Wallace, R. J. Rodabough, et al., J. Am. Med. Assoc. 293, 330 (2005).
V. Zimmer and F. Lammert, Curr. Opin. Gastroenterol. 27, 231 (2011).
R. L. Baron, C. A. Rohrmann, S. P. Lee, et al., Am. J. Roentgenol. 151, 1123 (1988).
E. I. Suvorova, V. V. Pantyushev, and A. E. Voloshin, Crystallogr. Rep. 62 (6), 817 (2017).
A. A. Il’chenko, Cholelithiasis (Anakharsis, Moscow, 2004) [in Russian].
C. Schafmayer, J. Hartleb, J. Tepel, et al., BMC Gastroenterol. 6, 36 (2006).
V. E. Asadchikov, A. V. Buzmakov, A. E. Voloshin, et al., Eksp. Klin. Gastroenterol., No. 7 (155), 118 (2018).
Funding
This study was supported by the Ministry of Science and Higher Education of the Russian Federation within the State assignment for the Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences in the part of carrying out experiments and by the Russian Foundation for Basic Research, project no. 18-29-26028, in the part of reconstructing images and analyzing results of microtomography experiments. XRD and electron microscopy experiments were performed using equipment of the Collective-Use Center of the Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences.
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Translated by Yu. Sin’kov
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Krivonosov, Y.S., Asadchikov, V.E., Buzmakov, A.V. et al. Physical Methods for Determining the Phase Composition of Gallstones. Crystallogr. Rep. 64, 920–925 (2019). https://doi.org/10.1134/S1063774519060117
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DOI: https://doi.org/10.1134/S1063774519060117