Abstract
Different types of enzymes in rotational macromolecular motors of living cells are presented based on the data in the literature. Particular attention has been given to the restriction–modification enzymes and helicases, in which conformational changes in sites are physical reasons of linear motions and rotation of DNA molecules (caused by polar forces). It is shown that the structure and functioning of enzymes, similar to those in chiral smectic C-type liquid crystals, can be described within the formalism of generalized forces and currents. These forces include the membrane electrochemical gradient, the velocity of rotor mechanical motion, and the measure of change in free energy in the “fuel” adenosine triphosphate molecule.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Reference
P. D. Boyer, Biophim. Biophys. Acta 1140 (3), 215 (1993).
R. Seidel, J. van Noort, C. van der Scheer, et al., Nature, Struct. Mol. Biol. 11 (9), 838 (2004).
E. J. Enemark and L. JoshuaTor, Nature 442, 270 (2006).
P. Abrahams, A. G. Leslie, R. Lutter, et al., Nature 370, 621 (1994).
P. D. Boyer, Annu. Rev. Biochem. 66, 717 (1997).
W. Junge, D. Sabbert, and S. Engelbrecht, Ber. Bunsen- Ges. Phys. Chem. 100, 2014 (1966).
G. Schulenberg, F. Wellmer, H. Lill, et al., Eur. J. Biochem. 249 (1), 134 (1997).
P. Dimroth, H. Wang, M. Grabe, et al., Proc. Natl. Acad. Sci. USA 96 (9), 4924 (1999).
W. Junge, Proc. Natl. Acad. Sci. USA PNAS 96 (9), 4735 (1999).
H. Noji, R. Yasuda, M. Yoshida, et al., Nature 386, 299 (1997).
P.-G. de Gennes, The Physics of Liquid Crystals (Clarendon Press, Oxford, 1974).
S. A. Pikin, Structural Transformations in Liquid Crystals (Gordon and Breach, New York, 1991).
V. Weber and A. E. Senior, Biochim. Biophys. Acta 1319 (1), 19 (1997).
F. Julicher, A. Ajdari, and J. Prost, Rev. Mod. Phys. 69, 1269 (1997).
S. Pikin and W. Haase, Zh. Eksp. Teor. Fiz. 119 (1), 99 (2001).
R. Gabler, Electric Interactions in Molecular Biophysics (Academic, New York, 1978).
D. T. F. Dryden, N. E. Murray, and D. N. Rao, Nucl. Acids Res. 29 (18), 3728 (2001).
J. H. White, Am. J. Math. 91 (3), 693 (1969).
S. A. Pikin, L. A. Beresnev, W. Haase, et al., Proc. EUROPTO Ser., Imag, Technol. 2949, 11 (1997).
A. Pingoud and A. Jeltsch, Eur. J. Biochem. 246 (1), 1 (1997).
S. A. Pikin, Crystallogr. Rep. 53, 858 (2008).
S. A. Pikin, Crystallogr. Rep. 52, 1094 (2007).
E. B. Loginov and S. A. Pikin, Crystallogr. Rep. 51, 308 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.A. Pikin, E.S. Pikina, 2018, published in Kristallografiya, 2018, Vol. 63, No. 5, pp. 734–741.
Rights and permissions
About this article
Cite this article
Pikin, S.A., Pikina, E.S. On DNA Motions under Action of Enzymes of Different Types. I. Crystallogr. Rep. 63, 753–760 (2018). https://doi.org/10.1134/S106377451805022X
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S106377451805022X