Abstract
Six 4-bromobenzohydrazide derivatives (1–6) were synthesized by the condensation reaction of 4-bromobenzohydrazide and benzaldehydes, and evaluated for antibacterial activity. Their structures were determined by spectroscopic methods. In addition, the crystal structure of compound 6 was characterized by single crystal X-ray structure determination. In crystal packing, the molecules are linked by N–H···O and N–H···N hydrogen bonds into two-dimensional network parallel to the (001) plane. The crystal is further stabilized by weak C–H···O and C–H···π interactions.
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Q. Wang, Y. Pan, J. Wang, Q. Peng, H. Luo, and J. Zheng, J. African J. Biotech. 10, 18013 (2011).
C. Loncle, J. M. Brunel, N. Vidal, M. Dherbomez, and Y. Letourneux, Eur. J. Med. Chem. 39, 1067 (2004).
R. P. Bhole and K. P. Bhusari, J. Korean Chem. Soc. 28, 1405 (2009).
S. J. Peng, J. Chem. Cryst. 14, 280 (2011).
K.-K. Bedia, O. Elcin, U. Seda, K. Fatma, S. Nathaly, R. Sevim, and A. Dimoglo, Eur. J. Med. Chem. 41, 1253 (2006).
P. Melnyk, V. Leroux, C. Sergheraert, and P. Grellier, Bioorg. Med. Chem. Lett. 16, 31 (2006).
K. K. V. Raj, B. Narayana, B. V.Ashalatha, N. S. Kumari, and B. K. Sarojini, Eur. J. Med. Chem. 42, 425 (2007).
APEX2, SAINT and SADABS (Bruker AXS, Madison, Wisconsin, USA, 2009).
G. M. Sheldrick, Acta Crystallogr. A 64, 112 (2008).
A. L. Spek, Acta Crystallogr. D 65, 148 (2009).
C. F. Macrae, P. R. Edginton, P. McCabe, E. Pidcook, G. P. Shields, R. Taylor, M. Towler, and J. van de Streek, J. Appl. Crystallogr. 39, 453 (2006).
F. H. Allen, O. Kennard, D. G. Watson, L. Brammer, A. G. Orpen, and R. Taylor, J. Chem. Soc. Perkin Trans 2, S1–19 (1987).
J. Horkaew, S. Chantrapromma, T. Anantapong, A. Kanjana-Opas, and H.-K. Fun, Acta Crystallogr. E68, o1069 (2012).
P. Promdet, J. Horkaew, S. Chantrapromma, and H.-K. Fun, Acta Crystallogr. E67, o3224 (2011).
A. Kanjana-Opas, Ph.D. Thesis, (University of Califonia, San Diego, USA, 2002).
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Chantrapromma, S., Ruanwas, P., Noonot, T. et al. Synthesis and antibacterial properties of 4-bromobenzohydrazide derivatives and crystal structure of (E)-N′-((1H-indol-3-yl)methylene)-4-bromobenzohydrazide. Crystallogr. Rep. 60, 1072–1079 (2015). https://doi.org/10.1134/S1063774515070068
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DOI: https://doi.org/10.1134/S1063774515070068