Crystallography Reports

, Volume 59, Issue 1, pp 117–124 | Cite as

Synchrotron X-ray diffraction study of the structure of oral stratum corneum model lipid membranes

  • N. Yu. RyabovaEmail author
  • A. Yu. Gruzinov
  • A. V. Zabelin
Liquid Crystals


Membranes modeling the lipid fraction of the mucous membrane of the human oral cavity have been studied by X-ray synchrotron diffraction. Ternary systems, composed of a mixture of sphingomyelin, dipalmitoylphosphatidylcholine, and dipalmitoylphosphatidylethanolamine with component weight ratios of 1: 2: 2 and 1: 2: 1, have lamellar structures in the gel phase at the physiological temperature (37°C). An inverted hexagonal phase is formed in the system with 40% dipalmitoylphosphatidylethanolamine in the temperature range of 60–70°C. This phase coexists with the liquid-crystalline lamellar phase in a narrow temperature range and completely surpresses the lamellar phase with an increase in temperature to 80°C. Multi-component oral stratum corneum membranes are characterized by several lamellar phases at 20–37°C and the coexistence of one or several lamellar phases with inverted hexagonal phase at 80–90°C.


Stratum Corneum Crystallography Report Lamellar Structure Hexagonal Phase DPPE 
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Copyright information

© Pleiades Publishing, Inc. 2014

Authors and Affiliations

  • N. Yu. Ryabova
    • 1
    • 2
    Email author
  • A. Yu. Gruzinov
    • 3
  • A. V. Zabelin
    • 3
  1. 1.Joint Institute for Nuclear ResearchDubna, Moscow oblastRussia
  2. 2.Skobeltsyn Institute of Nuclear PhysicsMoscow State UniversityMoscowRussia
  3. 3.National Research Centre “Kurchatov Institute”MoscowRussia

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