Formation of the long-periodicity phase in model membranes of the outermost layer of skin (Stratum corneum)
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Model SC membranes (lipid membranes fabricated from the main components of the lipid matrix of the outermost layer of mammalian skin (stratum corneum (SC)) are used to study the general regularities of the nanostructurization of SC lipid matrix. A model membrane from the outermost layer of skin SC with a composition ceramide 1/ceramide 6/cholesterol/palmitic acid/cholesterol sulfate and a component weight ratio of 30/30/20/15/5 has been investigated by X-ray diffraction. It is shown that the membrane structure at pH = 7.2 consists of two short-periodicity phases with repeat distances d = 47 and 35.7 Å and a long-periodicity phase with d = 127 Å. An increase in pH to 9.0 leads to destruction of the long-periodicity phase, while the short-periodicity phase is retained with d = 48.3 Å.
KeywordsStratum Corneum DPPC Crystallography Report Lipid Matrix Repeat Distance
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