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Improvement of Optoacoustic Angiographic Images Using One-Dimensional Deconvolution with Adaptive Real-Time Self-Calibration

  • ACOUSTICS OF LIVING SYSTEMS. BIOMEDICAL ACOUSTICS
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Abstract

This work introduces a method of one-dimensional deconvolution with Tikhonov regularization for enhancing three-dimensional optoacoustic images in vivo. The method employs adaptive self-calibration to eliminate frequency-dependent distortions associated with ultrasound propagation and detection. By adapting to the inhomogeneous frequency characteristics of the examined medium, the method eliminates the need for additional calibration experiments. The processing time for three-dimensional optoacoustic data of size 200 × 200 × 100 voxels is less than 5 ms, facilitating the real-time enhancement of angiographic images and improving the effective spatial resolution by more than 50%.

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ACKNOWLEDGMENTS

The authors acknowledge technical contribution to this work from the engineers of the IAP RAS: Maxim Prudnikov, Vladimir Vorobiev, Vyacheslav Kazakov, Roman Kobzev, Sergey Pozhidaev, and Valentina Kotomina.

Funding

The development of an optoacoustic microscope and the acquisition of experimental data were supported by the Russian Science Foundation, project no. 19-75-10055P. The studies on the capabilities of the Tikhonov deconvolution method with adaptive self-calibration and the optimization of the software for real-time deconvolution were conducted within the framework of financial support from the Ministry of Science and Higher Education of the Russian Federation for the National Center for Photonics, project no. 075-15-2022-316). MF and MJ acknowledge financial support from Swiss National Science Foundation (SNSF), project no. 205320-179038.

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Authors and Affiliations

  1. Institute of Applied Physics, Russian Academy of Sciences, 603155, Nizhny Novgorod, Russia

    E. M. Timanin, I. S. Mikhailova, I. I. Fiks, A. A. Kurnikov, A. V. Kovalchuk, A. G. Orlova, O. A. Ugarova & P. V. Subochev

  2. Institute of Applied Physics, University of Bern, 3012, Bern, Switzerland

    M. Frenz & M. Jaeger

Authors
  1. E. M. Timanin
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  2. I. S. Mikhailova
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  3. I. I. Fiks
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  4. A. A. Kurnikov
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  5. A. V. Kovalchuk
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  6. A. G. Orlova
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  7. O. A. Ugarova
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  8. M. Frenz
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  9. M. Jaeger
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  10. P. V. Subochev
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Corresponding authors

Correspondence to E. M. Timanin or P. V. Subochev.

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Translated by A. Ivanov

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Timanin, E.M., Mikhailova, I.S., Fiks, I.I. et al. Improvement of Optoacoustic Angiographic Images Using One-Dimensional Deconvolution with Adaptive Real-Time Self-Calibration. Acoust. Phys. 69, 914–920 (2023). https://doi.org/10.1134/S1063771023601176

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  • DOI: https://doi.org/10.1134/S1063771023601176

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