Abstract
A noninvasive ultrasound surgery method that relies on using multi-element focused phased arrays is being successfully used to destroy tumors and perform neurosurgical operations in deep structures of the human brain. However, several drawbacks that limit the possibilities of the existing systems in their clinical use have been revealed: a large size of the hemispherical array, impossibility of its mechanical movement relative to the patient’s head, limited volume of dynamic focusing around the center of curvature of the array, and side effect of overheating skull. Here we evaluate the possibility of using arrays of smaller size and aperture angles to achieve shock-wave formation at the focus for thermal and mechanical ablation (histotripsy) of brain tissue taking into account current intensity limitations at the array elements. The proposed approach has potential advantages to mitigate the existing limitations and expand the possibilities of transcranial ultrasound surgery.
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References
L. R. Gavrilov, Focused Ultrasound of High Intesity in Medicine (Fazis, Moscow, 2013) [in Russian].
W. J. Elias, D. Huss, T. Voss, J. Loomba, M. Khaled, E. Zadicario, R. C. Frysinger, S. A. Sperling, S. Wylie, S. J. Monteith, J. Druzgalm, B. B. Shahm, M. Harrison, and M. Wintermark, The New England J. Med. 369 (7), 640–648 (2013).
N. McDannold, G. Clement, P. Black, F. Jolesz, and K. Hynynen, Neurosurgery 66 (2), 323–332 (2010).
S. Monteith, R. Medel, N. F. Kassell, W. Wintermark, M. Eames, J. Snell, E. Zadicario, J. Grinfeld, J. P. Sheehan, and W. J. Elias, J. Neurosurgery 118 (2), 319–328 (2013).
D. Jeanmonod, B. Werner, A. Morel, L. Michels, E. Zadicario, G. Schiff, and E. Martin, Neurosurg. Focus. 32 (1), E1 (2012).
J. L. Thomas and M. A. Fink, IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 43 (6), 1122–1129 (1996).
K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24 (2), 275–283 (1998).
K. Hynynen and R. M. Jones, Phys. Med. Biol. 61 (1), 206–248 (2016).
O. A. Sapozhnikov, P. B. Rosnitskiy, and V. A. Khokhlova, in Program of 5th FUSF, 2016.
H. Odéen, J. de Bever, S. Almquist, A. Farrer, N. Todd, A. Payne, J. W. Snell, D. A. Christensen, and D. L. Parker, J. Therapeutic Ultrasound 2, Art. 19 (2014).
P. B. Rosnitskiy, S.A. Il’in, O. A. Sapozhnikov, and V. A. Khokhlova, Uchen. Zapiski Fiz. Fak. Mos. Univ. 4, 134301 (2013).
P. V. Yuldashev, S. M. Shmeleva, S. A. Ilyin, O. A. Sapozhnikov, L. R. Gavrilov, and V. A. Khokhlova, Phys. Med. Biol. 58 (8), 2537–2559 (2013).
V. A. Khokhlova, J. B. Fowlkes, Y. N. Wang, and C. A. Cain, Int. J. Hyperthermia 31 (2), 145–162 (2015).
J. Parsons, C. Cain, G. Abrams, and J. Fowlkes, Ultrasound Med. Biol. 32 (1), 115–129 (2006).
T. D. Khokhlova, M. S. Canney, V. A. Khokhlova, O. A. Sapozhnikov, L. A. Crum, and M. R. Bailey, J. Acoust. Soc. Am. 130 (5), 3498–3510 (2011).
T. Looi, V. A. Khokhlova, C. Mougenot, K. Hynynen, and J. Drake, in Program Booklet of the 16th Int. Symp. Therapeutic Ultrasound (Tel Aviv, Israel, 2016) pp. 64–66.
W. Kreider, P. V. Yuldashev, O. A. Sapozhnikov, N. Farr, A. Partanen, M. R. Bailey, and V. A. Khokhlova, IEEE Trans. Ultrason., Ferroelect., Freq. Contr. 60 (8), 1683–1698 (2013).
H. T. O’Neil, J. Acoust. Soc. Am. 21 (5), 516–526 (1949).
P. B. Rosnitskiy, P. V. Yuldashev, and V. A. Khokhlova, Acoust. Phys. 61 (3), 301–307 (2015).
S. A. Tsysar, V. A. Khokhlova, V. D. Svet, A. M. Molotilov, W. Kreider, and O. A. Sapozhnikov, in IEEE Int. Ultrasonics Symp. Proc. (Tours, France, 2016).
L. R. Gavrilov, O. A. Sapozhnikov, and V. A. Khokhlova, Bull. Russ. Acad. Sci.: Phys. 79 (10), 1232–1237 (2015).
V. A. Khokhlova, P. V. Yuldashev, P. B. Rosnitskiy, A. D. Maxwell, W. Kreider, M. R. Bailey, and O. A. Sapozhnikov, in Proc. 45th Ann. Symp. Ultrasonic Industry Assoc. (Seattle, USA, 2016)
S. A. Ilyin, P. V. Yuldashev, V. A. Khokhlova, P. B. Rosnitskiy, O. A. Sapozhnikov, and L. R. Gavrilov, Acoust. Phys. 61 (1), 52–59 (2015).
J. W. Hand, A. Shaw, N. Sadhoo, S. Rajagopal, R. J. Dickinson, and L. R. Gavrilov, Phys. Med. Biol. 54 (19), 5675–5694 (2009).
P. B. Rosnitskiy, P. V. Yuldashev, V. A. Khokhlova, and B. A. Vysokanov, Acoust. Phys. 62 (2), 151–159 (2016).
P. B. Rosnitskiy, P. V. Yuldashev, O. A. Sapozhnikov, A. D. Maxwell, W. Kreider, M. R. Bailey, and V. A. Khokhlova, IEEE Trans. Ultrason., Ferroelect., Freq. Contr. 2017 (accepted).
O. V. Bessonova, V. A. Khokhlova, M. R. Bailey, M. S. Canney, and L. A. Crum, Acoust. Phys. 55 (4–5), 463–473 (2009).
L. Marsac, Focalisation ultrasonore adaptative et application à la thérapie du cerveau // Paris 7. Ph. D. thesis. 2013.
S. A. Goss, L. A. Frizzell, and F. Dunn, Ultrasound Med. Biol. 5 (2), 181–186 (1979).
P. Ramaekers, M. Ries, C. T. Moonen, and M. de Greef, in Program of the 15th Int. Symp. for Therapeutic Ultrasound (2015) p. 174.
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Original Russian Text © P.B. Rosnitskiy, L.R. Gavrilov, P.V. Yuldashev, O.A. Sapozhnikov, V.A. Khokhlova, 2017, published in Akusticheskii Zhurnal, 2017, Vol. 63, No. 5, pp. 489–500.
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Rosnitskiy, P.B., Gavrilov, L.R., Yuldashev, P.V. et al. On the possibility of using multi-element phased arrays for shock-wave action on deep brain structures. Acoust. Phys. 63, 531–541 (2017). https://doi.org/10.1134/S1063771017050104
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DOI: https://doi.org/10.1134/S1063771017050104