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Effect of Hormonal Background on the Expression of Sex Hormone Receptors and the Migration Potential of Mouse Endometrial Epithelial and Stromal Cells In Vitro

  • DEVELOPMENTAL BIOLOGY OF ANIMALS (INVERTEBRATES AND VERTEBRATES)
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Abstract

Preparation for embryo implantation is a complex process that includes changes at both the cellular and tissue levels in the epithelium and stroma of the endometrium of the uterus. The success of pregnancy depends on the regulation of preimplantation changes in the endometrium and the onset of the receptivity period. Modeling the regulation of the functioning of the endometrium in vitro allows us to study the process of preparing the endometrium for embryo implantation, which is especially important for the development of therapeutic approaches for the treatment of diseases associated with infertility. The paper shows the effect of steroid sex hormones on the change in the polarity of the endometrial epithelium in vitro, which is also an important process during implantation in vivo. We also describe the mutual influence of estrogen and progesterone as the main regulators of endometrial functioning on the expression of their receptors.

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ACKNOWLEDGMENTS

The work was performed using the equipment of Core Centrum of Koltsov Institute of Developmental Biology, Russian Academy of Sciences.

Funding

The work was performed with the financial support of the grant of the Russian Science Foundation (project no. 21-74-30015).

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Authors and Affiliations

  1. Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, 119334, Moscow, Russia

    L. Sh. Izmailova, A. O. Gaidamaka, O. O. Serbina & E. A. Vorotelyak

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  1. L. Sh. Izmailova
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  2. A. O. Gaidamaka
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  3. O. O. Serbina
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  4. E. A. Vorotelyak
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Contributions

Izmailova Lyubov’ and Gaidamaka Anna performed experiments and wrote the text of the article, Serbina Olesya isolated RNA from all the samples, Vorotelyak Ekaterina planned the work and edited the text.

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Correspondence to L. Sh. Izmailova.

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Conflict of interest. The authors declare that they have no conflict of interests.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the use of animals in experiments and the animal care conditions have been met. People as objects did not participate in this study.

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Translated by A. Ermakov

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Izmailova, L.S., Gaidamaka, A.O., Serbina, O.O. et al. Effect of Hormonal Background on the Expression of Sex Hormone Receptors and the Migration Potential of Mouse Endometrial Epithelial and Stromal Cells In Vitro. Russ J Dev Biol 52, 401–413 (2021). https://doi.org/10.1134/S1062360421060060

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  • DOI: https://doi.org/10.1134/S1062360421060060

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