Skip to main content
Springer Nature Link
Log in

Formation and Transformation of the Human Prostate Gland in Prenatal and Neonatal Periods of Development

  • EMBRYOGENESIS AND CARCINOGENESIS
  • Published:
Russian Journal of Developmental Biology Aims and scope Submit manuscript

Abstract

The purpose of this study was to determine the morphometric parameters of epithelial cords, ducts, and acini of the human prostate gland and their lining epithelium, and the shape of prostate glands in prenatal and neonatal periods of development. The study was performed on serial histological sections of the pelvic region of 47 human prefetuses and fetuses and 10 prostate glands of boys of early and late neonatal periods. The shape and size of acini and lumens and the epithelial cells of epithelial cords, acini, and prostatic ducts were studied. The results showed that the formation and canalization of prostate epithelial cords were detected already in the early fetal period. The formation of prostatic ducts was not accompanied by an increase in their total area and was the result of differentiation of epithelial cells and apoptosis. It is shown that the size and shape of prostate glandular acini of neonates changed compared to the fetal periods. Conclusions. Prostate glandular acini form sequentially rather than directly from the epithelial cords: the latter are transformed into the prostatic ducts, from which the glandular acini are then formed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+
from $39.99 /Month
  • Starting from 10 chapters or articles per month
  • Access and download chapters and articles from more than 300k books and 2,500 journals
  • Cancel anytime
View plans

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

REFERENCES

  1. Akhtemiichuk, Yu.T., Relevance of scientific research in perinatal anatomy, Neonatol. Khirurg. Perinat. Med., 2012, vol. 2, no. 1 (3), pp. 15–21.

  2. Bruni-Cardoso, A. and Carvalho, H.F., Dynamics of the epithelium during canalization of the rat ventral prostate, Anat. Rec., 2007, vol. 290, pp. 1223–1232.

  3. Evtushenko, V.M., Syrtsov, V.K., Zidrashko, G.A., et al., Features of structural and functional organization of stromal and glandular cells of human prostate in the prenatal and postnatal ontogenesis, Ukr. Morfol. Al’manakh, 2011, vol. 3, no. 9, pp. 106–108.

    Google Scholar 

  4. Hayward, S.W., Baskin, L.S., and Haughney, P.C., Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle, Acta Anat., 1996, vol. 155, pp. 81–93.

    Article  CAS  PubMed  Google Scholar 

  5. Khudoerkov, R.M., Metody komp’yuternoi morfometrii v neiromorfologii (Methods of Computer Morphometry in Neuromorphology), Moscow: Nauch. Tsentr Nevrol., Ross. Akad. Med. Nauk, 2014.

  6. Khvatov, B.P. and Shapovalov, Yu.N., Rannii embriogenez cheloveka i mlekopitayushchikh: posobie (Early Embryogenesis of Humans and Mammals: Tutorial), Simferopol’, 1968.

  7. Lugin, I.A., Features of interstitial interactions in morphogenesis of organs with heterogeneous origin of tissue components, Svit Med. Biol., 2012, vol. 8, no. 4, pp. 77–79.

    Google Scholar 

  8. Lysyakov, S.N., Characteristics of prostate of human fetuses on week 20–21 of fetal development, Sovrem. Naukoemk. Tekhnol., 2010, no. 12, pp. 41–42.

  9. Mailleux, A.A., Overholtzer, M., Schmelzle, T., et al., BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms, Dev. Cell, 2007, no. 12, pp. 221–234.

  10. Marker, P.C., Donjacour, A.A., Dahiya, R., et al., Hormonal, cellular, and molecular control of prostatic development, Dev. Biol., 2003, vol. 253, pp. 165–174.

    Article  CAS  PubMed  Google Scholar 

  11. Mezhdunarodnye terminy po embriologii cheloveka s ofitsial’nym spiskom russkikh ekvivalentov (International Terms in Human Embryology with the Official List of Russian Equivalents), Kolesnikov, L.L, Shevlyuk, N.N., and Erofeeva, L.M., Eds., Moscow: GEOTAR-MEDIA, 2014.

    Google Scholar 

  12. Mytsik, A.V., The use of ImageJ software for automatic morphometry in histological studies, Omsk. Nauch. Vestn., 2011, vol. 100, no. 2, pp. 187–189.

    Google Scholar 

  13. Shapiro, E., Embryologic development of the prostate. Insights into the etiology and treatment of benign prostatic hyperplasia, Urol. Clin. North. Am., 1990, vol. 17, no. 3, pp. 487–493.

  14. Skibo, Yu.V. and Abramova, Z.I., Metody issledovaniya programmiruemoi kletochnoi gibeli: Uchebno-metodicheskoe posobie dlya magistrov po kursu “Teoriya apoptoza” (Methods of Study of Programmed Cell Death: A Study Guide for Masters on the Course “Theory of Apoptosis”), Kazan: Kazan. Fed. Univ., 2011.

  15. Skorodok, L.M. and Savchenko, O.N., Narusheniya polovogo razvitiya u mal’chikov (Disturbances in Sexual Development of Boys), Moscow: Meditsina, 1984.

  16. Sparks, R. and Madabhushi, A., Explicit shape descriptors: novel morphologic features for histopathology classification, Med. Image Anal., 2013, vol. 17, no. 8, pp. 997–1009.

    Article  PubMed  Google Scholar 

  17. Trotsenko, B.V. and Lugin, I.A., Regional mesenchymal heterogeneity during morphogenesis of the prostate gland in human and rat fetuses, Morfologiya, 2009, vol. 3, no. 3, pp. 126–130.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vitebsk State Order of Peoples’ Friendship Medical University, 210009, Vitebsk, Belarus

    I. A. Piatsko & A. K. Usovich

Authors
  1. I. A. Piatsko
    View author publications

    Search author on:PubMed Google Scholar

  2. A. K. Usovich
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to A. K. Usovich.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Piatsko, I.A., Usovich, A.K. Formation and Transformation of the Human Prostate Gland in Prenatal and Neonatal Periods of Development. Russ J Dev Biol 50, 90–94 (2019). https://doi.org/10.1134/S1062360419020036

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1062360419020036

Keywords: