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cGMP and epigenetic factor in the suppression of apoptosis in ovarian follicles

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Abstract

The role of cGMP (cyclic guanosine monophosphate) in the suppression of apoptosis in preantral and preovulatory follicles has been established. But the underlying mechanisms have not yet been established. The present study has been focused on revealing the mechanisms involved in the cGMP mediated suppression of apoptosis and in survival of ovarian follicle. cGMP reduces calcium burden of the cell by mediating Ca2+ channels, BK (Big Potassium) channels, phosphatidylinositol 3-kinase (PI3K)/Akt pathway thus, prevents the mitochondrial membrane pore formation and apoptosis. cGMP induces the expression of Trx (thioredoxin) protein and prevents the TNF-α (Tumour Necrosis factor) induced apoptosis. cGMP also induces the expression of cytoskeleton proteins which are involved in heterogeneous distribution of mitochondria and there by reduces the Ca2+ burden and apoptosis. Histone 3 lysine 4 methyltransferase (MLL2) is an epigenetic factor inhibits the transcription of genes involved apoptosis which acts as co-activator of Estrogen receptor-α. In conclusion the present review predicts some mechanisms underlying the cGMP mediated suppression of apoptosis in ovarian follicles.

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Authors and Affiliations

  1. Embryo Biotechnology Laboratory, Department of Physiology, College of Veterinary Science, Tirupati, 517502, India

    V. Praveen Chakravarthi & A. V. N. Siva kumar

  2. Division of Animal Biotechnology, Department of Zoology, Sri Venkateswara University, Tirupati, India

    Y. Sireesha & M. Bhaskar

  3. Biomedical Informatics Centre, Vector Control Research Centre, Indian Council of Medical Research, Pondicherry, 60500, India

    Y. Nanda Kumar

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  1. V. Praveen Chakravarthi
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  2. Y. Sireesha
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  3. Y. Nanda Kumar
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  4. A. V. N. Siva kumar
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  5. M. Bhaskar
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Correspondence to V. Praveen Chakravarthi.

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Chakravarthi, V.P., Sireesha, Y., Kumar, Y.N. et al. cGMP and epigenetic factor in the suppression of apoptosis in ovarian follicles. Russ J Dev Biol 47, 303–312 (2016). https://doi.org/10.1134/S1062360416060059

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