Russian Journal of Developmental Biology

, Volume 45, Issue 6, pp 297–312 | Cite as

Cajal bodies and histone locus bodies: Molecular composition and function

Reviews

Abstract

The review provides modern classification of evolutionarily conserved coilin-containing nuclear bodies of somatic and germ cells that is based on the characteristic features of their molecular composition and the nature of their functions. The main differences between Cajal bodies and histone locus bodies, which are involved in the biogenesis of small nuclear spliceosomal and nucleolar RNAs and in the 3′-end processing of histone precursor messenger RNA, respectively, are considered. It is shown that a significant contribution to the investigation of the diversity of coilin-containing bodies was made by the studies on the architecture of the RNA processing machinery in oocyte nuclei in a number of model organisms. The characteristics features of the molecular composition of coilin-containing bodies in growing oocyte nuclei (the so-called germinal vesicles) of vertebrates, including amphibians and birds, are described.

Keywords

coilin coilin-containing bodies oogenesis histone locus bodies Cajal bodies nuclear bodies oocyte nucleus 

Abbreviations

snRNAs

small nuclear RNAs

snRNP

small nuclear ribonucleoproteins

snoRNAs

small nucleolar RNAs

pre-mRNAs

precursor messenger RNAs

HS

hollow sphere

SG

solid globe

HLB

histone locus body

CB

Cajal body

scaRNAs

small Cajal body-specific RNAs

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Copyright information

© Pleiades Publishing, Inc. 2014

Authors and Affiliations

  1. 1.St. Petersburg State UniversitySt. PetersburgRussia

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