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Age-related changes in sensory neurons containing calcitonin gene-related peptide under conditions of afferentation deficit in rats

  • Developmental Physiology
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Abstract

Morphological features of calcitonin gene-related peptide (CGRP)-immunoreactive neurons were studied in the sensory ganglia of the vagus and thoracic nerves in 3-, 10-, 20-, 30-, 60-, 90-, and 180-day-old rats under conditions of chemically-induced deafferentation. We found that, in rats, CGRP-containing neurons appeared in both ganglia immediately after they were born and their number decreased with aging. Most of CGRP-immunoreactive neurons were small in size, i.e., up to 600 μm2. Administration of capsaicin modified age-related changes in the number of CGRP-immunopositive neurons. In the thoracic nerve ganglion, the mean square of these cells and their number substantially decreased, whereas, in the vagus nerve ganglion, positive cells were not observed.

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Authors and Affiliations

  1. Ministry of Health and Social Development of the Russian Federation, Yaroslavl State Medical Academy, ul. Revolyutsionnaya 5, Yaroslavl, 150000, Russia

    V. V. Porseva, A. A. Strelkov, V. V. Shilkin & P. M. Maslyukov

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  1. V. V. Porseva
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  2. A. A. Strelkov
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  3. V. V. Shilkin
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  4. P. M. Maslyukov
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Correspondence to V. V. Porseva.

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Original Russian Text © V.V. Porseva, A.A. Strelkov, V.V. Shilkin, P.M. Maslyukov, 2012, published in Ontogenez, 2012, Vol. 43, No. 6, pp. 405–412.

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Porseva, V.V., Strelkov, A.A., Shilkin, V.V. et al. Age-related changes in sensory neurons containing calcitonin gene-related peptide under conditions of afferentation deficit in rats. Russ J Dev Biol 43, 335–341 (2012). https://doi.org/10.1134/S1062360412060069

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  • DOI: https://doi.org/10.1134/S1062360412060069

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