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Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats

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Abstract

Experimental data were reviewed which demonstrated that the neonatal injection effects of certain biologically active drugs (ACTH4–10 fragment and its analogue Semax, piracetam, caffeine, levetiracetam, busperone, etc.) could be detected in adult animals as changes in physiological and behavioral reactions and in several morphological traits as well. Audiogenic seizures proneness, anxiety-fear and exploration behavior as well as pain sensitivity were analyzed. The remote effects discovered were either similar in direction to those applied to an adult organism, or opposite to it. Pharmacological treatments of such type presumably interfere the CNS development during early postnatal ontogeny and change the normal pattern of brain development. These modulatory influences could be due to changes in neurotransmitter system development and are presumably capable to induce CNS morphological deviations (numbers of neurons, adult neurogenesis).

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References

  • Agrawal, A.K. and Shapiro, B.H., Neonatal Phenobarbital Imprints Overexpression of Cytochromes P450 with Associated Increase in Tumorigenesis and Reduced Life Span, FASEB J., 2005, vol. 19, no. 3, pp. 470–472.

    PubMed  CAS  Google Scholar 

  • Alekseev, V.V., Koshelev, V.B., Kovalev, G.I., and Poletaeva, I.I., Effects of Neonatal Treatments on Pain and Audiogenic Sensitivity and Brain Content of Monoamines in Adult Rats, Russ. J. Dev. Biol., 2003a, vol. 34, no. 6, pp. 389–395.

    Article  CAS  Google Scholar 

  • Alekseev, V.V., Salonin, D.V., Fedotova, I.B., and Poletaeva, I.I., Nociceptive Thresholds in Adult Rats of Three Strains after Pain Stimulation in the Neonatal Period, Bull. Exp. Biol. Med., 2003b, vol. 135, no. 4, pp. 388–389.

    Article  PubMed  CAS  Google Scholar 

  • D’Amato, F.R., Mazzacane, E., Capone, F., et al., Effects of Postnatal Manipulation on Nociception and Morphine Sensitivity in Adult Mice, Physiol. Behav., 2001, vol. 66, no. 4, pp. 627–637.

    Google Scholar 

  • Ammassari-Teule, M., Fagioli, S., Maritati, M., et al., Chronic Administration of Phosphatidylserine during Ontogeny Enhances Subject-Environment Interactions and Radial Maze Performance in C57BL/6 Mice, Physiol. Behav., 1990, vol. 47, no. 4, pp. 755–760.

    Article  PubMed  CAS  Google Scholar 

  • Anand, K.J. and Bhutta, A.T., Vulnerability of the Developing Brain. Neuronal Mechanisms, Clin. Perinatol., 2002, vol. 29, no. 3, pp. 357–372.

    Article  PubMed  Google Scholar 

  • Blandova, Z.K., Dushkin, V.A., Malashenko, A.M., et al., Linii laboratornykh zhivotnykh dlya mediko-biologicheskikh issledovanii (Lines of Laboratory Animals for Biomedical Research), Moscow: Nauka, 1983.

    Google Scholar 

  • Boyarshinova, O.S., Shilova, O.B., Markina, N.V., et al., Genotype-Dependent Changes in Pain Thresholds in Adult Mice after Neonatal Treatment, Bull. Exp. Biol. Med., 2004a, vol. 137, no. 6, pp. 532–535.

    Article  PubMed  CAS  Google Scholar 

  • Boyarshinova, O.S., Revishchin, A.V., Poletaeva, I.I., and Korochkin, L.I., Neonatal Administration of ACTH4-10 and Its Analog Semax to Young Laboratory Mice Modulates the Number of Catecholaminergic Neurons in Adult Animal Diencephalon, Dokl. Biol. Sci., 2004b, vol. 396, pp. 181–183.

    Article  PubMed  CAS  Google Scholar 

  • Boyarshinova, O.S., Perepelkina, O.V., Markina, N.V., et al., Audiogenic Epilepsy in Young Mice of Different Strains after Neonatal Semax Treatment, Bull. Exp. Biol. Med., 2008, vol. 145, no. 7, pp. 94–97.

    Google Scholar 

  • Bozdagi, O., Rich, E., Tronel, S., Sadahiro, M., et al., The Neurotrophin-Inducible Gene Vgf Regulates Hippocampal Function and Behavior through a BDNF-Dependent Mechanism, J. Neurosci., 2008, vol. 28, no. 39, pp. 9857–9869.

    Article  PubMed  CAS  Google Scholar 

  • Brown, R.W., Perna, M.K., Schaefer, T.L., et al., The Effects of Adulthood Nicotine Treatment on D2-Mediated Behavior and Neurotrophins of Rats Neonatally Treated with Quinpirole, Synapse, 2006, vol. 59, no. 5, pp. 253–259.

    Article  PubMed  CAS  Google Scholar 

  • Chen, C.S., Gates, G.R., and Reynoldson, J.A., Effect of Morphine and Naloxone on Priming-Induced Audiogenic Seizures in BALB/c Mice, Br. J. Pharmac., 1976, vol. 58, pp. 517–520.

    Article  CAS  Google Scholar 

  • Cohen, M.A., Skelton, M.R., Schaefer, T.L., et al., Learning and Memory after Neonatal Exposure to 3,4-Methylenedioxymethamphetamine (Ecstasy) in Rats: Interaction with Exposure in Adulthood, Synapse, 2005, vol. 57, pp. 148–159.

    Article  PubMed  CAS  Google Scholar 

  • Costei, A.M., Kozer, E., Ho, T., et al., Perinatal Outcome Following Third Trimester Exposure to Paroxetine, Arch. Pediatr. Adolesc. Med., 2002, vol. 156, pp. 1129–1132.

    Article  PubMed  Google Scholar 

  • Counotte, D.S., Spijker, S., Van de Burgwal, L.H., et al., Long-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats, Neuropsychopharmacology, 2009, vol. 34, pp. 299–306.

    Article  PubMed  CAS  Google Scholar 

  • Crews, D., Epigenetics and Its Implications for Behavioral Neuroendocrinology, Front. Neuroendocrinol., 2008, vol. 29, no. 3, pp. 344–357.

    Article  PubMed  CAS  Google Scholar 

  • Dall’Igna, O.P., Da Silva, A.L., Dietrich, M.O., et al., Chronic Treatment with Caffeine Blunts the Hyperlocomotor but not Cognitive Effects of the N-Methyl-D-Aspartatereceptor Antagonist MK-801 in Mice, Psychopharmacology, 2003, vol. 166, no. 3, pp. 258–263.

    PubMed  Google Scholar 

  • Dassesse, D., Vanderwinden, J.M., Goldberg, I., et al., Caffeine-Mediated Induction of C-Fos, Zif-268 and Arc Expression through A1 Receptors in the Striatum: Different Interactions with the Dopaminergic System, Eur. J. Neurosci., 1999, vol. 11, no. 9, pp. 3101–3114.

    Article  PubMed  CAS  Google Scholar 

  • Dubynin, V.A., Malinovskaya, I.V., Ivleva, Yu.A., et al., Delayed Behavioral Effects of Beta-Casomorphin-7 Depend on Age and Gender of Albino Rat Pups, Bull. Exp. Biol. Med., 2001, vol. 130, no. 11, pp. 488–492.

    Google Scholar 

  • Faingold, C.L., Neuronal Networks in the Genetically Epilepsy-Prone Rat, Adv. Neurol., 1999, vol. 79, pp. 311–321.

    PubMed  CAS  Google Scholar 

  • File, S.E. and Tucker, J.C., Prenatal Treatment with Clomipramine Has an Anxiolytic Profile in the Adolescent Rat, Physiol. Behav., 1983, vol. 31, no. 1, pp. 57–61.

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald, M. and Beggs, S., The Neurobiology of Pain: Developmental Aspects, Neuroscicence, 2001, vol. 7, no. 3, pp. 246–257.

    CAS  Google Scholar 

  • Gao, H.-R., Shi, T.-F., Yang, C.-X., et al., The Effect of Dopamine on Pain-Related Neurons in the Parafascicular Nucleus of Rats, J. Neur. Transmis., 2010, vol. 117, no. 5, pp. 585–591.

    Article  CAS  Google Scholar 

  • Grunau, R., Early Pain in Preterm Infants. A Model of Long-Term Effects, Clin. Perinatol., 2002, vol. 29, no. 3, pp. 373–394.

    Article  PubMed  Google Scholar 

  • Guillet, R., Neonatal Caffeine Exposure Alters Seizure Susceptibility in Rats in an Age-Related Manner, Brain Res. Dev. Brain Res., 1995, vol. 89, no. 1, pp. 124–128.

    Article  PubMed  CAS  Google Scholar 

  • Henry, K.R., Audiogenic Seizure Susceptibility Induced in C57B1/6J Mice by Prior Auditory Exposure, Science, 1967, vol. 158, pp. 938–940.

    Article  PubMed  CAS  Google Scholar 

  • Kaindl, A.M. and Ikonomidou, C., Glutamate Antagonists Are Neurotoxins for the Developing Brain, Neurotox. Res., 2007, vol. 11, nos. 3–4, pp. 203–218.

    Article  PubMed  CAS  Google Scholar 

  • Koch, S.C., Fitzgerald, M., and Hathway, G.J., Midazolam Potentiates Nociceptive Behavior, Sensitizes Cutaneous Reflexes, and Is Devoid of Sedative Action in Neonatal Rats, Anesthesia, 2008, vol. 108, no. 1, pp. 122–129.

    Article  CAS  Google Scholar 

  • Korogodina, Yu.V. and S’yakste, T.G., 101/H Line Mice, a Possible Model of Human Chromosomal Instability Diseases, Genetika, 1981, vol. 17, no. 5, pp. 915–919.

    PubMed  CAS  Google Scholar 

  • Kuznetsova, G.D., Petrova, E.V., Coenen, A.M., et al., Generalized Absence Epilepsy and Catalepsy in Rats, Physiol. Behav., 1996, vol. 60, no. 4, pp. 1165–1169.

    Article  PubMed  CAS  Google Scholar 

  • Liang, J., Wang, X., Lu, Y., et al., Effects of Antidepressants on the Exploration, Spontaneous Motor Activity and Isolation-Induced Aggressiveness in Mice, Beijing: Da Xue Xue Bao, 2003, vol. 35, no. 1, pp. 54–60.

    Google Scholar 

  • Loepke, A.W., Istaphanous, G.K., McAuliffe, J.J., et al., The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory, Intern. Anesth. Res. Soc., 2009, vol. 108, no. 1, pp. 90–104.

    CAS  Google Scholar 

  • Maguire, J. and Mody, I., GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression, Neuron, 2008, vol. 59, pp. 207–213.

    Article  PubMed  CAS  Google Scholar 

  • Maple, A.M., Perna, M.K., Joshua, P., et al., Ontogenetic Quinpirole Treatment Produces Long-Lasting Decreases in the Expression of Rgs9, but Increases Rgs17 in the Striatum, Nucleus Accumbens and Frontal Cortex, Eur. J. Neurosci., 2007, vol. 26, no. 9, pp. 2532–2538.

    Article  PubMed  Google Scholar 

  • Markina, N.V., Shilova, O.B., Perepelkina, O.V., et al., Neonatal Administration of Buspiron Causes Changes in Intermale Aggression of Adult Mice, Dokl. Akad. Nauk, 2004, vol. 396, no. 2, pp. 1–3.

    Google Scholar 

  • Markina, N.V., Perepelkina, O.V., and Poletaeva, I.I., The Remote Effects of Neonatal Injections of Caffeine and Piracetam on Audiogenic Seizure Susceptibility in Mice of Three Genotypes, Zh. Vysch. Nerv. Deyat. im. I.P. Pavlova, 2006, vol. 58, no. 3, pp. 424–431.

    Google Scholar 

  • Markina, N.V., Perepelkina, O.V., Bizikoeva, F.Z., et al., Neonatal Buspirone Modulates the Intermale Aggression in Adult Mice, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2006, vol. 56, no. 4, pp. 491–498.

    CAS  Google Scholar 

  • Maxson, S.C. and Sze, P.Y., Glucocorticoids and Development of Audiogenic Seizure Susceptibility in DBA/1Bg Mice, Behav. Genet., 1977, vol. 7, pp. 323–326.

    Article  PubMed  CAS  Google Scholar 

  • McGivern, R.F., Rose, G., Berka, C., et al., Neonatal Exposure to a High Level of ACTH4-10 Impairs Adult Learning Performance, Pharmacol. Biochem. Behav., 1987, vol. 27, no. 1, pp. 133–142.

    Article  PubMed  CAS  Google Scholar 

  • Mehta, M., Ahmed, Z., Fernando, S.S., et al., Plasticity of 5-HT 1A Receptor-Mediated Signaling during Early Postnatal Brain Development, J. Neurochem., 2007, vol. 101, no. 4, pp. 918–928.

    Article  PubMed  CAS  Google Scholar 

  • Middaugh, L.D., Boggan, W.O., and Shepherd, C.L., Prenatal Ethanol Effects and Dopamine Systems of Adult C57 Male Mice, Neurotoxicol. Teratol., 1994, vol. 16, no. 2, pp. 207–212.

    Article  PubMed  CAS  Google Scholar 

  • Midzyanovskaya, I.S., Kuznetsova, G.D., Vinogradova, L.V., et al., Mixed Forms of Epilepsy in a Subpopulation of WAG/Rij Rats, Epilepsy Behav., 2004, vol. 5, no. 5, pp. 655–661.

    Article  PubMed  Google Scholar 

  • Mooney, S.M. and Miller, M.W., Role of Neurotrophins on Postnatal Neurogenesis in the Thalamus: Prenatal Exposure to Ethanol, Neuroscience, 2011, Jan 25 [Epub ahead of print].

  • Morford, L.L., Inman-Wood, S.L., Gudelsky, G.A., et al., Impaired Spatial and Sequential Learning in Rats Treated Neonatally with D-Fenfuramine, Eur. J. Neurosci., 2002, vol. 16, pp. 491–500.

    Article  PubMed  CAS  Google Scholar 

  • Mothes, H.K., Opitz, B., Werner, R., et al., Effects of Prenatal Ethanol Exposure and Early Experience on Home-Cage and Open-Field Activity in Mice, Neurotoxicol. Teratol., 1996, vol. 18, no. 1, pp. 59–65.

    Article  PubMed  CAS  Google Scholar 

  • Murray, P.D., Masri, R., and Keller, A., Abnormal Anterior Pretectal Nucleus Activity Contributes to Central Pain Syndrome, J. Neurophysiol., 2009, vol. 102, pp. 181–191.

    Article  PubMed  Google Scholar 

  • Noorlander, C.W., Ververs, F.F.T., Nikkels, P.G.J., et al., Modulation of Serotonin Transporter Function during Fetal Development Causes Dilated Heart Cardiomyopathy and Lifelong Behavioral Abnormalities, PLoS ONE, 2008, vol. 3, no. 7, p. e2782.

    Article  PubMed  Google Scholar 

  • Peters, J.W., Schouw, R., Anand, K.J., et al., Does Neonatal Surgery Lead to Increased Pain Sensitivity in Later Childhood?, Pain, 2005, vol. 114, no. 3, pp. 444–454.

    Article  PubMed  Google Scholar 

  • Peunova, N., Scheinker, V., Cline, H., et al., Nitric Oxide Is an Essential Negative Regulator of Cell Proliferation in Xenopus Brain, J. Neurosci., 2001, vol. 21, no. 22, pp. 8809–8818.

    PubMed  CAS  Google Scholar 

  • Pick, C.G., Cooperman, M., Trombka, D., et al., Hippocampal Cholinergic Alterations and Related Behavioral Deficits after Early Exposure to Ethanol, Int. J. Dev. Neurosci., 1993, vol. 11, no. 3, pp. 379–385.

    Article  PubMed  CAS  Google Scholar 

  • Poletaeva, I.I., Lil’p, I.G., Irisova, O.A., et al., An Unusual Type of Locomotion in Mice of Line 101/HY, Genetika, 1992, vol. 28, no. 12, pp. 147–149.

    PubMed  CAS  Google Scholar 

  • Poletaeva, I.I., Shilova, O.B., and Korochkin, L.I., The Effect of ACTH4-10 on the Behavior of Several Inbred Strains of Mice, Russ. J. Dev. Biol., 1996a, vol. 27, no. 4, pp. 294–299.

    CAS  Google Scholar 

  • Poletaeva, I.I., Lil’p, I.G., Bizikoeva, F.Z., et al., Audiogenic Epilepsy in Mouse Strain 101/HY at Different Stages of Postnatal Ontogenesis, Russ. J. Dev. Biol., 1996b, vol. 27, no. 3, pp. 188–196.

    Google Scholar 

  • Porter, F.L., Grunau, R.E., and Anand, K.J., Long-Term Effects of Pain in Infants, J. Dev. Behav. Pediatr., 1999, vol. 20, no. 4, pp. 253–261.

    Article  PubMed  CAS  Google Scholar 

  • Puchalski, M. and Hummel, P., The Reality of Neonatal Pain, Adv. Neon. Care, 2002, vol. 5, pp. 233–244.

    Google Scholar 

  • Rasakham, K. and Liu-Chen, L.Y., Sex Differences in Kappa Opioid Pharmacology, Life Sci., 2011, vol. 88, nos. 1–2, pp. 2–16.

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto, T., Mishina, M., and Niki, H., Mutation of NMDA Receptor Subunit Epsilon 1: Effects on Audiogenic-Like Seizures Induced by Electrical Stimulation of the Inferior Colliculus in Mice, Mol. Brain Res., 2002, vol. 102, no. 1–2, pp. 113–117.

    Article  PubMed  CAS  Google Scholar 

  • Salonin, D.V., Perepelkina, O.V., Markina, N.V., et al., The Influence of Neonatal Ketamine Injection on Pain Sensitivity and Audiogenic Seizures in Adult Rats, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2004, vol. 54, no. 2, pp. 277–282.

    CAS  Google Scholar 

  • Sánchez, C., Arnt, J., Hyttel, J., et al., The Role of Serotonergic Mechanisms in Inhibition of Isolation-Induced Aggression in Male Mice, Psychopharmacology (Berl.), 1993, vol. 110, nos. 1–2, pp. 53–59.

    Article  Google Scholar 

  • Savina, T.A., Fedotova, I.B., Semiokhina, A.F., et al., Remote Effects of Early Postnatal Pituitary Hormone Melatonin Injection on Audiogenic Seizures in Krushinsky-Molodkina Rats, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2005, vol. 55, no. 1, pp. 117–125.

    CAS  Google Scholar 

  • Schroeder, H., Humbert, A.-C., Desor, D., et al., Long-Term Consequences of Neonatal Exposure to Diazepam on Cerebral Glucose Utilization, Learning, Memory and Anxiety, Brain Res., 1997, vol. 766, nos. 1–2, pp. 142–152.

    Article  PubMed  CAS  Google Scholar 

  • Semiokhina, A.F., Fedotova, I.B., and Poletaeva, I.I., Rats of Krushinsky-Molodkina Strain: Studies of Audiogenic Epilepsy, Vascular Pathology, and Behavior, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2006, vol. 56, no. 2, pp. 249–267.

    Google Scholar 

  • Shadrina, M., Kolomin, T., Agapova, T., et al., Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina under Semax Action, J. Mol. Neurosci., 2010, vol. 41, no. 1, pp. 30–35.

    Article  PubMed  CAS  Google Scholar 

  • Shibuya, T., Watanabe, Y., Hill, H.F., et al., Developmental Alterations in Maturing Rats Caused by Chronic Prenatal and Postnatal Diazepam Treatments, Jpn. J. Pharmacol., 1986, vol. 40, no. 1, pp. 21–29.

    Article  PubMed  CAS  Google Scholar 

  • Shilova, O.B., Orlova, E.O., Kovalev, G.I., et al., Strain-Specific Response to a Neonatal Injection of the ACTH4–10 Fragment in Mice: Behaviour, Neurochemistry, and Brain Morphology, Russ. J. Genet., 2000, vol. 36, no. 11, pp. 1267–1272.

    CAS  Google Scholar 

  • Shilova, O.B, Markina, N.V., Perepelkina, O.V., et al., Neonatal Semax and Saline Injections Induce Open-Field Behavior Changes in Mice of Different Genotypes, Zh. Vyssh. Nervn. Deyat. im. I.P. Pavlova, 2004, vol. 54, no. 6, pp. 785–794.

    CAS  Google Scholar 

  • Slotkin, T.A., Fetal Nicotine or Cocaine Exposure: Which One Is Worse?, J. Pharmacol. Exp. Ther., 1998, vol. 285, no. 3, pp. 931–945.

    PubMed  CAS  Google Scholar 

  • Táira, T., Porkka-Heiskanen, T., and Korpi, E.R., Neonatal Administration of a GABA-T Inhibitor Alters Central GABAA Receptor Mechanisms and Alcohol Drinking in Adult Rats, Psychopharmacology (Berl.), 1992, vol. 109, nos. 1–2, pp. 191–197.

    Article  Google Scholar 

  • Táira, T., Uusi-Oukari, M., and Korpi, E.R., Early Postnatal Treatment with Muscimol Transiently Alters Brain GABA-A Receptors and Open-Field Behavior in Rat, Eur. J. Pharmacol., 1993, vol. 230, no. 3, pp. 307–312.

    Article  PubMed  Google Scholar 

  • Tchekalarova, J., Kubová, H., and Mares, P., Effects of Postnatal Caffeine Exposure on Seizure Susceptibility in Developing Rats, Brain Res., 2007, vol. 1150, pp. 32–39.

    Article  PubMed  CAS  Google Scholar 

  • Timoshenko, T.V., Perepelkina, O.V., Markina, N.V., et al., Audiogenic Epilepsy in Mice with Different Genotypes after Neonatal Treatments Enhancing Neurogenesis in Dentate Gyrus, Bull. Exp. Biol. Med., 2009a, vol. 147, no. 4, pp. 458–461.

    Article  PubMed  CAS  Google Scholar 

  • Timoshenko, T.V., Revishchin, A.V., Pavlova, G.V., et al., Effect of Neonatal Injections of the Neuropeptide Semax on Cell Proliferation in Hippocampal Dentate Area in Rats of Two Genotypes, Dokl. Biol. Sci., 2009b, vol. 424, pp. 78–80.

    Article  PubMed  CAS  Google Scholar 

  • Venerosi, A., Calamandrei, G., and Alleva, E., Animal Models of Anti-HIV Drugs Exposure during Pregnancy: Effects on Neurobehavioral Development, Prog. Neuropsychopharm. Biol. Psych., 2002, vol. 26, no. 4, pp. 747–761.

    Article  CAS  Google Scholar 

  • Venerosi, A., Cutuli, D., Colonnello, V., et al., Neonatal Exposure to Chlorpyrifos Affects Maternal Responses and Maternal Aggression of Female Mice in Adulthood, Neurotoxicol. Teratol., 2008, vol. 30, no. 6, pp. 468–474.

    Article  PubMed  CAS  Google Scholar 

  • Viggedal, G., Hagberg, B.S., Laegreid, L., et al., Mental Development in Late Infancy after Prenatal Exposure to Benzodiazepines-A Prospective Study, J. Child Psychol. Psych., 1993, vol. 34, no. 3, pp. 295–305.

    Article  CAS  Google Scholar 

  • Vorhees, C.V., Developmental Neurotoxicity Induced by Therapeutic and Illicit Drugs, Env. Health Persp., 1994, vol. 102, Suppl. 2, pp. 145–153.

    Google Scholar 

  • Vorhees, C.V., Schaefer, T.L., Skelton, M.R., et al., (+/−) 3,4-Methylenedioxymethamphetamine (MDMA) Dose-Dependently Impairs Spatial Learning in the Morris Water Maze after Exposure of Rats to Different Five-Day Intervals from Birth to Postnatal Day Twenty, Dev. Neurosci., 2009, vol. 31, nos. 1–2, pp. 107–120.

    Article  PubMed  CAS  Google Scholar 

  • Wang, C.Z., Yang, S.F., Xia, Y., et al., Postnatal Phencyclidine Administration Selectively Reduces Adult Cortical Parvalbumin-Containing Interneurons, Neuropsychopharmacology, 2008, vol. 33, pp. 2442–2455.

    Article  PubMed  CAS  Google Scholar 

  • Williamsa, M.T., Blankenmeyer, T.L., Schaefera, T.L., et al., Long-Term Effects of Neonatal Methamphetamine Exposure in Rats on Spatial Learning in the Barnes Maze and on Cliff Avoidance, Corticosterone Release, and Neurotoxicity in Adulthood, Dev. Brain Res., 2003, vol. 147, pp. 163–175.

    Article  Google Scholar 

  • Williamsa, M.T., Moran, M.S., and Vorhees, C.V., Behavioral and Growth Effects Induced by Low Dose Methamphetamine Administration during the Neonatal Period in Rats, Int. J. Dev. Neurosci., 2004, vol. 22, nos. 5–6, pp. 273–283.

    Article  Google Scholar 

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Authors and Affiliations

  1. Moscow State University, Moscow, 119992, Russia

    I. I. Poletaeva, O. V. Perepelkina, O. S. Boyarshinova, I. G. Lil’p, N. V. Markina & T. B. Timoshenko

  2. Institute for Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia

    A. V. Revishchin

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  1. I. I. Poletaeva
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  2. O. V. Perepelkina
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  3. O. S. Boyarshinova
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  4. I. G. Lil’p
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  6. T. B. Timoshenko
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Original Russian Text © I.I. Poletaeva, O.V. Perepelkina, O.S. Boyarshinova, I.G. Lil’p, N.V. Markina, T.B. Timoshenko, A.V. Revishchin, 2012, published in Ontogenez, 2012, Vol. 43, No. 6, pp. 387–400.

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Poletaeva, I.I., Perepelkina, O.V., Boyarshinova, O.S. et al. Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats. Russ J Dev Biol 43, 319–331 (2012). https://doi.org/10.1134/S1062360412060045

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