Skip to main content
SpringerLink
Log in

Where and when natriuretic peptides are secreted in the heart

  • Developmental Physiology
  • Published:
Russian Journal of Developmental Biology Aims and scope Submit manuscript

Abstract

This review presents recent data on the structure, synthesis, and secretion of cardiac natriuretic peptides. It is known that these hormones have a broad spectrum of activity, but they remain the least studied and poorly understood link in the regulation of the water-salt homeostasis. Emphasis is placed on the problem of ontogenetic formation of the heart secretory activity during embryogenesis. We discuss the available scarce and scattered information on the paracrine and autocrine effects of the peptides on intercellular interactions, and on the division, growth and differentiation of the heart cells. These issues are hardly addressed in Russian literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baertschi, A.J., Monnier, D., Schmidt, U., et al., Acid Prohormone Sequence Determines Size, Shape, and Docking of Secretory Vesicles in Atrial Myocytes, Circ. Res., 2001, vol. 89, pp. E23–E29.

    Article  PubMed  CAS  Google Scholar 

  • de Bold, A.J., Borenstein, H.B., Veress, A.T., et al., A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats, Life. Sci., 1981, vol. 28, pp. 89–94.

    Article  PubMed  Google Scholar 

  • de Bold, A.J., Bruneau, B.G., and de Bold, M.L., Mechanical and Neuroendocrine Regulation of the Endocrine Heart, Cardiovasc. Res., 1996, vol. 31, pp. 7–18.

    Article  PubMed  Google Scholar 

  • Cameron, V.A. and Ellmers, L.J., Minireview: Natriuretic Peptides during Development of the Fetal Heart and Circulation, Endocrinology, 2003, vol. 144, no. 6, pp. 2191–2194.

    Article  PubMed  CAS  Google Scholar 

  • Christoffersen, C., Goetze, J.P., Bartels, E.D., et al., Chamber-Dependent Expression of Brain Natriuretic Peptide and Its mRNA in Normal and Diabetic Pig Heart, Hypertension, 2002, vol. 40, pp. 54–60.

    Article  PubMed  CAS  Google Scholar 

  • Clerico, A. and Emdin, M., Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review, Clin. Chem., 2004, vol. 50, pp. 33–50.

    Article  PubMed  CAS  Google Scholar 

  • Deloof, S., VanCamp, G., and Chatelain, A. Molecular Forms of Atrial Natriuretic Peptide in Atria and Plasma from Fetal and Adult Female Rats, Biol. Neonate, 1995, vol. 68, pp. 292–300.

    Article  PubMed  CAS  Google Scholar 

  • D’souza, S.P., Davis, M., and Baxter, G.F., Autocrine and Paracrine Actions of Natriuretic Peptides in the Heart, Pharmacol. Ther., 2004, vol. 101, no. 2, pp. 113–129.

    Article  PubMed  Google Scholar 

  • Feng, J.A., Perry, G., Miri, T., et al., Pressure-Independent Enhancement of Cardiac Hypertrophy in Atrial Natriuretic Peptide-Deficient Mice, Clin. Exp. Pharmacol. Physiol., 2003, vol. 30, nos. 5–6, pp. 343–349.

    Article  PubMed  CAS  Google Scholar 

  • Goetze, J.P., Biosynthesis of Cardiac Natriuretic Peptides, Results and Problems in Cell Differentiation, Springer-Verlag, 2009.

  • Hino, J., Tateyama, H., Minamino, N., et al., Isolation and Identification of Human Brain Natriuretic Peptides in Cardiac Atrium, Biochem. Biophys. Res. Commun., 1990, vol. 167, pp. 693–700.

    Article  PubMed  CAS  Google Scholar 

  • Iida, H. and Shibata, Y., Phasic Secretion of Newly Synthesized Atrial Natriuretic Factor from Unstimulated Atrial Myocytes in Culture, Circ. Res., 1994, vol. 74, pp. 659–668.

    PubMed  CAS  Google Scholar 

  • Ito, Y., Marumo, F., Ando, K., et al., The Physiological and Biological Significances of Human Atrial Natriuretic Peptide in Neonates, Acta Paediatr. Scand., 1990, vol. 79, no. 1, pp. 26–31.

    Article  PubMed  CAS  Google Scholar 

  • John, S.W., Krege, J.H., Oliver, P.M., et al., Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension, Science, 1995, vol. 267, pp. 679–681.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, D., Singh, M., and Cheung, C., Effect of Three Hours of Hypoxia on Atrial Natriuretic Factor Gene Expression in the Ovine Fetal Heart, Am. J. Obstet. Gynecol., 1997, vol. 176, pp. 42–48.

    Article  PubMed  CAS  Google Scholar 

  • Kawakami, H., Okayama, H., Hamada, M., et al., Alteration of Atrial Natriuretic Peptide and Brain Natriuretic Peptide Gene Expression Associated with Progression and Regression of Cardiac Hypertrophy in Renovascular Hypertensive Rats, Clin. Sci., 1996, vol. 90, pp. 197–204.

    PubMed  CAS  Google Scholar 

  • Kikuchi, K., Shiomi, M., Horie, K., et al., Plasma Atrial Natriuretic Polypeptide Concentration in Healthy Children from Birth to Adolescence, Acta Paediatr. Scand., 1988, vol. 77, no. 3, pp. 380–384.

    Article  PubMed  CAS  Google Scholar 

  • Knowles, J., Esposito, G., Mao, L., et al., Pressure Independent Enhancement of Cardiac Hypertrophy in Natriuretic Peptide Receptor A Deficient Mice, J. Clin. Invest., 2001, vol. 107, pp. 975–984.

    Article  PubMed  CAS  Google Scholar 

  • Koide, M., Akins, R.E., Harayama, H., et al., Atrial Natriuretic Peptide Accelerates Proliferation of Chick Embryonic Cardiomyocytes in vitro, Differentiation, 1996, vol. 61, no. 1, pp. 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Korostyshevskaya, I.M. and Maksimov, V.F., The Ultrastructural Features of Hormone-Producing Cardiomyocytes in Some Experimental and Clinical Conditions, Arkhiv AGE, 1989, no. 2, pp. 42–49.

  • Krylova, M.I., Hemogranin A: Immunocytochemical Localization in Secretory Granules of Atrial Cardiomyocytes of the Frog, Tsitologiia, 2007, vol. 49, no. 7, pp. 538–543.

    PubMed  CAS  Google Scholar 

  • Kudoh, S., Akazawa, H., Takano, H., et al., Stretch-Modulation of Second Messengers: Effects on Cardiomyocyte Ion Transport, Prog. Biophys. Mol. Biol., 2003, vol. 82, pp. 57–66.

    Article  PubMed  CAS  Google Scholar 

  • Lanfear, D.E., Genetic Variation in the Natriuretic Peptide System and Heart Failure, Heart Fail. Rev., 2010, vol. 15, no. 3, pp. 219–228.

    Article  PubMed  CAS  Google Scholar 

  • Maack, T., The Broad Homeostatic Role of Natriuretic Peptides, Arq. Bras. Endocrinol. Metab., 2006, vol. 50, no. 2, pp. 198–207.

    Article  Google Scholar 

  • McFarlane, S.I., Winer, N., and Sowers, J.R., Role of the Natriuretic Peptide System in Cardiorenal Protection, Arch. Intern. Med., 2003, vol. 163, pp. 2696–2704.

    Article  PubMed  CAS  Google Scholar 

  • Mohammed, S.F., Korinek, J., Chen, H.H., et al., Nesiritide in Acute Decompensated Heart Failure: Current Status and Future Perspectives, Rev. Cardiovasc. Med., 2008, vol. 9, pp. 151–158.

    PubMed  Google Scholar 

  • Mulay, S. and Varma, D.R., Placental Barrier to Atrial Natriuretic Peptide in Rats, Can. J. Physiol. Pharmacol., 1989, vol. 67, no. 1, pp. 1–4.

    Article  PubMed  CAS  Google Scholar 

  • Muth, E., Driscoll, W.J., Smalstig, A., et al., Proteomic Analysis of Rat Atrial Secretory Granules: A Platform for Testable Hypotheses, Biochim. Biophys. Acta, 2004, vol. 1699, nos. 1–2, pp. 263–275.

    PubMed  CAS  Google Scholar 

  • Navaratnam, V., Woodward, J.M., and Skepper, J.N., Specific Heart Granules and Natriuretic Peptide in the Developing Myocardium of Fetal and Neonatal Rats and Hamsters, J. Anat., 1989, vol. 163, pp. 261–273.

    PubMed  CAS  Google Scholar 

  • Nir, A., Lindinger, A., Rauh, M., et al., NT-Pro-B-Type Natriuretic Peptide in Infants and Children: Reference Values Based on Combined Data from Four Studies, Pediatr. Cardiol., 2009, vol. 30, no. 1, pp. 3–8.

    Article  PubMed  Google Scholar 

  • Ogawa, T., Vatta, M., Bruneau, B.G., et al., Characterization of Natriuretic Peptide Production by Adult Heart Atria, Am. J. Physiol. Heart. Circ. Physiol., 1999, vol. 276, no. 6, pp. 1977–1986.

    Google Scholar 

  • O’Donnell, P.J., Driscoll, W.J., Back, N., et al., Peptidylglycine-Alpha-Amidating Monooxygenase and Pro-Atrial Natriuretic Peptide Constitute the Major Membrane-Associated Proteins of Rat Atrial Secretory Granules, J. Mol. Cell. Cardiol., 2003, vol. 35, no. 8, pp. 915–922.

    Article  PubMed  Google Scholar 

  • Potter, L.R., Abbey-Hosch S., and Dickey, D.M., Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions, Endocrine Rev., 2006, vol. 22, no. 1, pp. 47–72.

    Google Scholar 

  • Rakhcheeva, M.L., Bugrova, M.L., Mukhina, I.V., and Zhabereva, A.S., The Role of Atrial Natriuretic Peptide in the Regulation of Blood Pressure in Unilateral Renal Ischemia in Rats, Vestn. Nizhegorod. Univ. im. N.I. Lobachevskogo, 2009, no. 6, no. 1, pp. 132–136.

  • Ruskoaho, H., Atrial Natriuretic Peptide: Synthesis, Release, and Metabolism, Pharmacol. Rev., 1992, vol. 44, pp. 479–602.

    PubMed  CAS  Google Scholar 

  • Stebbing, P., Gude, N., King, R., et al., α-Atrial Natriuretic Peptide-Induced Attenuation of Vasoconstriction in the Fetal Circulation of the Human Isolated Perfused Placenta, J. Perinat. Med., 1996, vol. 24, pp. 253–260.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, T.J. and Pipkin, F.B., Atrial Natriuretic Factor: The Heart as an Endocrine Organ, Arch. Dis. Child., 1990, vol. 65, pp. 1293–1294.

    Article  PubMed  CAS  Google Scholar 

  • Tamura, N., Ogawa, Y., Chusho, H., et al., Cardiac Fibrosis in Mice Lacking Brain Natriuretic Peptide, Proc. Natl. Acad. Sci. USA, 2000, vol. 97, pp. 4239–4244.

    Article  PubMed  CAS  Google Scholar 

  • Tse, M.Y., Watson, J.D., Sarda, I.R., et al., Expression of B-Type Natriuretic Peptide in Atrial Natriuretic Peptide Gene Disrupted Mice, Mol. Cell. Biochem., 2001, vol. 219, pp. 99–105.

    Article  PubMed  CAS  Google Scholar 

  • Vesely, D.L., Atrial Natriuretic Peptides in Pathophysiological Diseases, Cardiovasc. Res., 2001, vol. 51, pp. 647–658.

    Article  PubMed  CAS  Google Scholar 

  • Vesely, D.L., Which of the Cardiac Natriuretic Peptides Is Most Effective for the Treatment of Congestive Heart Failure, Renal Failure and Cancer?, Clin. Exper. Pharm. Physiol., 2006, vol. 33, no. 3, pp. 169–176.

    Article  CAS  Google Scholar 

  • Wei, Y., Rodi, C.P., Day, M.L., et al., Developmental Changes in the Rat Atriopeptin Hormonal System, J. Clin. Invest., 1987, vol. 79, pp. 1325–1329.

    Article  PubMed  CAS  Google Scholar 

  • Weidemann, A., Klanke, B., Wagner, M., et al., Hypoxia, via Stabilization of the Hypoxia-Inducible Factor HIF-1alpha, Is a Direct and Sufficient Stimulus for Brain-Type Natriuretic Peptide Induction, Biochem. J., 2008, vol. 409, pp. 233–242.

    Article  PubMed  CAS  Google Scholar 

  • Woodard, G.E. and Rosado, J.A., Recent Advances in Natriuretic Peptide Research, J. Cell. Mol. Med., 2007, vol. 11, no. 6, pp. 1263–1271.

    Article  PubMed  CAS  Google Scholar 

  • Wu, Q., Xu-Cai Y.O., Chen, S., et al., Corin: New Insights into the Natriuretic Peptide System, Kidney Int., 2009, vol. 75, no. 2, pp. 142–146.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, F. and Pasumarthi, K.B., Ultrastructural and Immunocharacterization of Undifferentiated Myocardial Cells in the Developing Mouse Heart, J. Cell. Mol. Med., 2007, vol. 11, no. 3, pp. 552–560.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, ul. Timakova 4, Novosibirsk, 630117, Russia

    I. M. Korostyshevskaya & V. F. Maksimov

Authors
  1. I. M. Korostyshevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. F. Maksimov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. M. Korostyshevskaya.

Additional information

Original Russian Text © I.M. Korostyshevskaya, V.F. Maksimov, 2012, published in Ontogenez, 2012, Vol. 43, No. 3, pp. 217–228.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korostyshevskaya, I.M., Maksimov, V.F. Where and when natriuretic peptides are secreted in the heart. Russ J Dev Biol 43, 185–195 (2012). https://doi.org/10.1134/S1062360412030046

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1062360412030046

Keywords

Search

Navigation