Abstract
The present study shows the effectiveness of using polyunsaturated fatty acids in pregnant rats in order to prevent behavioral alterations in neonatal rats caused by the action of the pathogenic peptide factors of blood serum with perinatal damage of the central nervous system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abdaladze, N.S., Avaliani, T.V., Chebotar’, N.A., et al., Embryotoxic Effect in Rats Caused by Blood Serum of Newborn Children Tested for the Presence of Transfer Factors, Ontogenez, 1994, vol. 25, no. 1, pp. 38–43.
Ataeva, O.V., Abdaladze, N.S., Lazarenko, N.S., et al., Loco-motor and Direction-Finding Behavior of Young Rats in Normal State and in Experimentally Induced Pathology, Zh. Vyssh. Nerv. Deyat., 1993, vol. 43, no. 1, pp. 150–156.
Avaliani, T.V. and Chebotar’, N.A., Polyunsaturated Fatty Acids Reduce Induced Pathological Lesions in Young Rats, Zh. Evol. Biokhim. Fiziol., 2002, vol. 38, no. 1, pp. 62–65.
Avaliani, T.V., Chebotar’, N.A., Ignat’eva, T.V., et al., Effect of Amniotic Fluid Taken from Women during Child Delivery on the Morphofunctional Development of Fetuses and Newborn Rats, Zh. Evol. Biokhim. Fiziol., 1992, vol. 28, no. 1, pp. 126–129.
Avaliani, T.V., Nezgovorova, I.V., Abdaladze, N.S., et al., Biotesting of Pregnant Women as a Method for Assessing the Risk of Locomotor Disturbances in Newborns, Ekol. Chelov., 1994, no. 1, pp. 33–36.
Azhgikhin, I.S., Ter-Karapetyan, V.A., Gandel’, V.G., and Arakelova, N.N., Docosahexaenoic and Eicosapentaenoic Acids: New Pharmaceutical and Medicinal Aspects, Farmatsiya, 1987, vol. 36, no. 2, pp. 80–90.
Baranovskii, A.Yu., Rukovodstvo po dietologii (A Guide on Dietology), St. Petersburg: Piter, 2001.
Barashnev, Yu.I., Perinatal’naya nevrologiya (Perinatal Neurology), Moscow: Triada-X, 2005.
Capper, J., Wilkinson, R.G., Mackenzie, A.M., et al., Polyunsaturated Fatty Acids Supplementation during Pregnancy Alters Neonatal Behavior in Sheep, J. Nutr., 2006, vol. 136, no. 2, pp. 397–403.
Dodkhoev, D.S., Evsyukova, I.I., and Baiborodov, B.D., Permeability of Erythrocytic Membranes and Sorption Capacity of Erythrocytes in Newborns after Hypoxia, Pediatriya, 2000, no. 1, pp. 101–102.
Hibbeln, J.R., Davis, J.M., Steer, C., et al., Maternal Seafood Consumption in Pregnancy and Neurodevelopment Outcomes in Childhood (ALSPAC Study): An Observational Cohort Study, Lancet, 2007, vol. 369, pp. 578–585.
Krylov, Yu.F., Lyubimov, I.B., and Mulyar, A.G., Prospects of Use of Eicosapentaenoic and Docosahexaenoic Acids as Drugs, Khim.-Farm. Zh., 1991, vol. 25, no. 9, pp. 4–9.
Makrides, M. and Gibson, RA., Long-Chain Polyunsaturated Fatty Acid Requirements during Pregnancy and Lactation, Am. J. Clin. Nutr., 2000, vol. 71, no. 1, p. 307.
Mikheeva, I.G., Ryukert, E.N., Brusov, O.S., et al., Serotonin Content in Blood Serum of Newborn Children with Hypoxic-Ischemic CNS Lesions, Pediatriya, 2008, vol. 87, no. 1, pp. 40–44.
Nezgovorova, I.V., Avaliani, T.V., Bogdanov, O.V., et al., Biotesting of Blood Serum and Liquor in Early Postnatal Period, Pediatriya, 1994, no. 4, pp. 46–49.
Obukhova, G.P., Seliverova, S.G., Varlinskaya, E.I., et al., Neuromorphological Analysis of the Motor Region of Cerebral Cortex of Rat Pups Administered with Normal and Pathologically Changed Blood Serum during Prenatal Development, Zh. Evol. Biokhim. Fiziol., 1992, vol. 28, no. 4, pp. 510–517.
Pal’chik, A.B. and Shabalov, N.P., Gipoksicheski-ishemicheskaya entsefalopatiya novorozhdennykh (Hypoxic-Ischemic Encephalopathy of Newborns), Moscow: Medpress-inform, 2006.
Petrukhina, G.N., Remov, M.N., Makarov, V.A., et al., Effect of Chronic Administration of Epaden and Acetylsalicylic Acid to Rabbits on the Antithrombotic Potential of the Vascular Wall, Zh. Eksp. Klin. Farmakol., 2002, vol. 65, no. 1, pp. 46–52.
Prakhin, E.I. and Tereshchenko, S.Yu., Plasma Membrane Lipids and Inflammatory Lipid Mediators in Children with Atopic Diseases: Their Role in Pathogenesis and Possible Correction Methods, Pediatriya, 2000, no. 2, pp. 82–88.
Raygada, M., Cho, E., and Hilakivi-Clarke, L., High Maternal Intake of Polyunsaturated Fatty Acids during Pregnancy in Mice Alters Offspring’ Aggressive Behavior, Immobility in the Swim Test, Locomotor Activity and Brain Protein Kinase C Activity, J. Nutr., 1998, vol. 128, no. 12, pp. 2505–2511.
Reznik, B.Ya., Pasenyuk, T.A., and Artemenko, I.P., Phospholipid Spectrum and Parameters of Lipid Peroxidation of Liquor in Newborns with Perinatal CNS Lesions, Pediatriya, 1990, no. 10, pp. 20–21.
Ter-Karapetyan, V.A., Pharmacological Correction of Lipid Metabolism, Hemostasis Systems, and Hemorheology with Epadem in Cerebrovascular Diseases, Extended Abstract of Doctoral (Med.) Dissertation, St. Petersburg: NIIEM RAMN, 1993.
Zhuravin, I.A., Tumanova, N.L., and Vasil’ev, D.S., Structural Changes in Hippocampal Neural Tissue in Rat Ontogeny after Prenatal Hypoxia, Zh. Evol. Biokhim. Fiziol., 2009, vol. 45, no. 1, pp. 138–140.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.V. Avaliani, N.S. Abdaladze, N.S. Lazarenko, V.M. Klimenko, 2010, published in Ontogenez, 2010, Vol. 41, No. 3, pp. 221–227.
Rights and permissions
About this article
Cite this article
Avaliani, T.V., Abdaladze, N.S., Lazarenko, N.S. et al. Polyunsaturated fatty acids prevent the development of locomotor disturbances caused by changes in the neurohumoral background in rat pups. Russ J Dev Biol 41, 183–188 (2010). https://doi.org/10.1134/S1062360410030070
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1062360410030070