Abstract
Carotenoids were found for the first time in the vitreous body of human eye during the fetal period from week 15 until week 28. Their maximum content was timed to week 16–22. No carotenoids were found the vitreous body of 31-week fetuses, as well as adult humans, which corresponds to the published data. It was shown using HPLC that chromatographic characteristics of these carotenoids correspond to those of lutein and zeaxanthin, characteristic pigments of the retinal yellow macula.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernstein, P.S., Khachik, F., Carvalho, L.S., et al., Identification and Quantitation of Carotenoids and Their Metabolites in the Tissues of the Human Eye, Exp. Eye Res., 2001, vol. 72, pp. 215–223.
Bhosale, P., Larson, A.J., Frederick, J.M., et al., Identification and Characterization of a Pi Isoform of Glutathione S-Transferase (GSTP1) as a Zeaxanthin-Binding Protein in the Macula of the Human Eye, J. Biol. Chem., 2004, vol. 279, no. 47, pp. 49447–49454.
Bone, R.A., Landrum, J.T., Fernandez, L., et al., Analysis of the Macular Pigment by HPLC: Retinal Distribution and Age Study, Invest. Ophthalmol. Vis. Sci., 1988, vol. 29, no. 6, pp. 843–849.
Bone, R.A., Landrum, J.T., Hime, G., et al., Stereochemistry of the Human Macular Carotenoids, Invest. Ophthalmol. Vis. Sci., 1993, vol. 34, pp. 2033–2040.
Bone, R.A., Landrum, J.T., Fernandez, L., et al., Distribution of Lutein and Zeaxanthin Stereoisomers in the Human Retina, Exp. Eye Res., 1997, vol. 64, pp. 211–218.
Govardovskii, V.I. and Zueva, L.V., High-Speed Microspectrophotometer for Studying Photolysis of Visual Pigments in situ, Sens. Sist., 2000, vol. 14, pp. 288–296.
Hammond, B.R., Wooten, B.R., and Snodderly, D.M., Density of the Human Crystalline Lens Is Related to the Macular Pigment Carotenoids, Lutein and Zeaxanthin, Invest. Ophtalmol Optom. Vis. Sci, 1997, vol. 74, pp. 499–504.
Hendrickson, A, A Morphological Comparison of Foveal development in Man and Monkey, Eye, 1992, vol. 6, pp. 136–144.
Hogan, V.J., Alvarado, J.A., and Weddel, J.E., Histology of the Human Eye, Philadelphia: Saunders, 1971.
Hollenberg, M.J. and Spira, A.W., Human Retinal Development: Ultrastructure of the Outer Retina, Am. J. Anat., 1973, vol. 137, no. 4, pp. 357–386.
Mann, I., The Development of the Human Eye, London: Brit. Med. Assoc, 1949.
Nag, T.C. and Wadhwa, S., Differential Expression of Syntaxin-1 and Synaptophysin in the Developing and Adult Human Retina, J. Biosci., 2001, vol. 26, no. 2, pp. 179–191.
Narayanan, K. and Wadhwa, S., Photoreceptor Morphogenesis in the Human Retina: A Scanning Electron Microscopic Study, Anat. Rec., 1998, vol. 252, pp. 133–139.
Panova, I.G. and Tatikolov, A.S., Finding of Albumin inhuman Vitreous Body Using Cyanine Dye as a Probe, Dokl. Akad. Nauk, 2005, vol. 402, no. 5, pp. 709–711.
Panova, I.G., Podgornyi, O.V., Markitantova, Yu.V., et al., Expression of Photoreceptor Specific Protein Recoverin at the Early Stages of Human Retina Prenatal Development: Immunocytochemical and Molecular-Biological Studies, Oftal’mologiya, 2006, vol. 3, no. 1, pp. 20–25.
Panova, I.G., Sharova, N.P., Dmitrieva, S.B., et al., The Use of a Cyanine Dye as a Probe for Albumin and Collagen in the Extracellular Matrix, Anal. Biochem., 2007, vol. 361, no. 2, pp. 183–189.
Peters, Jr., T., All About Albumin: Biochemistry, Genetics, and Medical Application, New York: Academic, 1996.
Sabah, J., McConkey, E., Welti, R., et al., Role of Albumin as Fatty Acid Carrier for Biosynthesis of Lens Lipids, Exp. Eye Res., 2005, vol. 80, pp. 31–36.
Trofimova, N.N., Zak, P.P., and Ostrovskii, M.A., Functional Role of Carotenoids of Retinal Macula; A Review of Data for Recent Decade, Sens. Sist., 2003, vol. 17, no. 3, pp. 198–208.
Yeum, K.J., Taylor, A., Tang, G., et al., 1995. Measurement of Carotenoids, Retinoids, and Tocopherols in Human Lenses, Invest. Ophthalmol. Vis. Sci., 1995, vol. 36, pp. 2756–2761.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © M.A. Yakovleva, I.G. Panova, T.B. Fel’dman, P.P. Zak, A.S. Tatikolov, G.T. Sukhikh, M.A. Ostrovsky, 2007, published in Ontogenez, 2007, Vol. 38, No. 5, pp. 380–385.
Rights and permissions
About this article
Cite this article
Yakovleva, M.A., Panova, I.G., Fel’dman, T.B. et al. Finding of carotenoids in the vitreous body of human eye during prenatal development. Russ J Dev Biol 38, 317–321 (2007). https://doi.org/10.1134/S1062360407050062
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1134/S1062360407050062