Abstract
Current concepts of the structure of immune proteasomes and their role in immune response have been considered. The main attention has been paid to the formation of immune proteasomes in secondary lymphoid and nonlymphoid organs during ontogenesis of mammals. The causes of ineffective formation of immune system in early postnatal development have been discussed.
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Abramova, E.B., Sharova, N.P., and Karpov, V.L., Proteasome: To Destroy in Order to Live, Mol. Biol., 2002, vol. 36, no. 5, pp. 761–776.
Astakhova, T.M. and Sharova, N.P., A Study of Immune Proteasomes from Cells of Mouse Ascite Carcinoma Krebs-II, Izv. Akad. Nauk, Ser. Biol., 2006, no. 3, pp. 275–283.
Cascio, P., Hilton, C., Kisselev, A.F., et al., 26S Proteasomes and Immunoproteasomes Produce Mainly N-Extended Versions of an Antigenic Peptide, EMBO J., 2001, vol. 20, pp. 2357–2366.
Dahlmann, B., Ruppert, T., Kuehn, L., et al., Different Proteasome Subtypes in a Single Tissue Exhibit Different Enzymatic Properties, J. Mol. Biol., 2000, vol. 303, pp. 643–653.
Dahlmann, B., Ruppert, T., Kloetzel, P.M., et al., Subtypes of 20S Proteasomes from Skeletal Muscle, Biochimie, 2001, vol. 83, pp. 295–299.
Eleuteri, A.M., Kohanski, R.A., Cardozo, C., and Orlowski, M., Bovine Spleen Multicatalytic Proteinase Complex (Proteasome). Replacement of X, Y, and Z Subunits by LMP7, LMP2, and MECL1 and Changes in Properties and Specificity, J. Biol. Chem., 1997, vol. 272, pp. 11824–11831.
Galaktionov, V.G., Immunologiya (Immunology), Moscow: Akademiya, 2004.
Griffin, T.A., Nandi, D., Cruz, M., et al., Immunoproteasome Assembly. Cooperative Incorporation of Interferon (IFN-)-Inducible Subunits, J. Exp. Med., 1998, vol. 187, pp. 97–104.
Groettrup, M., Standera, S., Stohwasser, R., et al., The Subunits MECL-1 and LMP2 Are Mutually Required for Incorporation Into the 20S Proteasome, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 8970–8975.
Janeway, D.A. and Travers, P., Immunobiology. The Immune System in Health and Disease, London: Cur. Biol., 1994.
Nil, A., Firat, E., Sobek, V., et al., Expression of Housekeeping and Immunoproteasome Subunit Genes Is Differentially Regulated in Positively and Negatively Selecting Thymic Stroma Subsets, Eur. J. Immunol., 2004, vol. 34, pp. 2681–2689.
Rock, K.L. and Goldberg, A.L., Degradation of Cell Proteins and the Generation of MHC Class I-Presented Peptides, Annu. Rev. Immunol., 1999, vol. 17, pp. 739–779.
Sharova, N.P., Immune Proteasomes and Immunity, Ontogenez, 2006, vol. 37, no. 3, pp. 111–118.
Shimbara, N., Nakajima, H., Tanahashi, N., et al., Double-Cleavage Production of the CTL Epitope by Proteasome and PA28: Role of the Flanking Region, Genes Cells, 1997, vol. 2, pp. 785–800.
Tanaka, K. and Ichihara, A., Half-Life of Proteasomes (Multiprotease Complexes) in Rat Liver, Biochem. Biophys. Res. Commun. 1989, vol. 159, pp. 1309–1315.
Toes, R.E.M., Nussbuam, A.K., Degermann, S., et al., Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products, J. Exp. Med., 2001, vol. 194, pp. 1–12.
Van Rees, E.P., Dijkstra, C.D., and Sminia, T., Ontogeny of the Rat Immune System: An Immunohistochemical Approach, Devel. Comp. Immunol., 1990, vol. 14, pp. 9–18.
Yarilin, A.A., Osnovy immunologii (Foundations of Immunology), Moscow: Meditsina, 1999.
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Original Russian Text © N.P. Sharova, T.M. Astakhova, L.A. Bondareva, S.B. Dmitrieva, S.D. Stolyarov, 2007, published in Ontogenez, 2007, Vol. 38, No. 5, pp. 323–329.
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Sharova, N.P., Astakhova, T.M., Bondareva, L.A. et al. Formation of immune proteasomes and development of immune system in ontogenesis of mammals. Russ J Dev Biol 38, 265–271 (2007). https://doi.org/10.1134/S1062360407050013
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DOI: https://doi.org/10.1134/S1062360407050013