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Differentiation antigens of hemoblastoses and epithelial tumors: Relations to the mechanisms of transformation and progression

  • Biology of Tumor Growth
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Abstract

The role of mechanisms underlying differentiation is considered in malignant transformation of hemoblastoses and epithelial tumors. In hemoblastoses, differentiation is intimately related to malignant transformation and they are underlain by the same mechanisms. Immunophenotyping of hemoblastoses is fully based on successive stages of their differentiation with characteristic expression of differentiation antigens. Unlike hemoblastoses, epithelial tumors gradually, in the course of progression, lose their differentiation due to the degradation of the connections with the microenvironment, which controls the direction and level of epithelial differentiation. Therefore, carcinomas are characterized by varying degrees of “antigenic simplification”, including the epithelial-mesenchymal transition.

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  1. Institute of Carcinogenesis, Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 24, Moscow, 115478, Russia

    G. I. Abelev

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  1. G. I. Abelev
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Original Russian Text © G.I. Abelev, 2006, published in Ontogenez, 2006, Vol. 37, No. 3, pp. 227–233.

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Abelev, G.I. Differentiation antigens of hemoblastoses and epithelial tumors: Relations to the mechanisms of transformation and progression. Russ J Dev Biol 37, 187–192 (2006). https://doi.org/10.1134/S1062360406030076

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  • DOI: https://doi.org/10.1134/S1062360406030076

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