Abstract
The influence of the lipid complex isolated from the thallus of the red marine algae Ahnfeltia tobuchiensis (LCA) on the metabolic parameters of the blood and liver of rats under a high-fat diet was studied. It was shown that the administration of LCA had a pronounced lipid-correcting and antioxidant effect, which was superior to that of the “Omega 3-6-9” reference preparation in terms of its ability to restore lipid metabolism, the ratio of lipoprotein fractions, and the indices of the endogenous antioxidant protection system; in addition it prevented the development of hepatosis. The lipid-correcting and antioxidant effect of LCA is specified by the action of n-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, which are part of the structure of phospholipids and glycolipids of marine origin and make up the main part of the studied lipid complex.
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This study was carried out within the framework of a State Assignment, project no. 0211-2021-0014, “Ecological and Biochemical Processes in Marine Ecosystems: The Role of Natural and Anthropogenic Factors” (state registration no. 121-21500052-9).
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Animal studies were carried out in accordance with the order of the Ministry of Health and Social Development of Russia of April 1, 2016, no. 199n “On Approval of the Rules of Laboratory Practice” and the requirements of GOST R 53434-2009 “Principles of Good Laboratory Practice.” This study was approved by the Bioethics Commission of the Il’ichev Pacific Oceanological Institute of the Far Eastern Branch of the Russian Academy of Sciences (protocol No. 16 dated April 15, 2021). The experiments were performed in accordance with the requirements of the Federation of European Laboratory Animal Science Associations (FELASA) in compliance with the “Regulations and International Recommendations of the European Convention for the Protection of Vertebrate Animals Used for Experiments or Other Scientific Purposes” (Strasbourg, 1986).
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Sprygin, V.G., Kushnerova, N.F., Fomenko, S.E. et al. Lipid-Correcting and Antioxidant Effects of the Lipid Complex from the Red Marine Algae Ahnfeltia tobuchiensis under the Conditions of a High-Fat Diet. Biol Bull Russ Acad Sci 51, 37–46 (2024). https://doi.org/10.1134/S1062359023601982
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DOI: https://doi.org/10.1134/S1062359023601982