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Evaluation of the Biological Effects of Ozone and Electromagnetic Pulses under Combined Exposure from an Electric Discharge Unit

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Abstract

The pilot research results of the biological effects of pulsed EMF and ozone combined exposure in the acute experiment are presented. The combined exposure conditions were produced by operation of the electric discharge unit over 100 minutes. The biological objects were laboratory male rats with body weight of 200–280 g. The clinical condition of laboratory animals, their research activity, pathomorphological and hematological parameters, and the antioxidant system markers were assessed 40 minutes after the end of exposure. The behavior inhibition, pronounced pilomotor reaction, lightening of hematological samples color, as well as the increase in the macropreparation activity of the heart and intestines in the automatism period were observed in the experimental group rats in comparison with the group of sham exposed rats. The activation of the antioxidant defense system was also observed in the dynamics of biochemical markers. The results obtained indicated the need to follow the research on electric discharge factors in combined exposure effects for occupational hygienic and therapeutic purposes.

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Authors and Affiliations

  1. Central Scientific Research Institute of the Ministry of Defense, Sergiev Posad, Russia

    N. N. Gavrish & S. G. Maksimov

  2. Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, Moscow, Russia

    I. B. Ushakov

  3. Izmerov Research Institute of Occupational Health, Moscow, Russia

    S. Yu. Perov & O. V. Belaya

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  1. N. N. Gavrish
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  2. I. B. Ushakov
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  3. S. G. Maksimov
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  4. S. Yu. Perov
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Correspondence to S. Yu. Perov.

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Gavrish, N.N., Ushakov, I.B., Maksimov, S.G. et al. Evaluation of the Biological Effects of Ozone and Electromagnetic Pulses under Combined Exposure from an Electric Discharge Unit. Biol Bull Russ Acad Sci 49, 2336–2341 (2022). https://doi.org/10.1134/S1062359022120056

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  • DOI: https://doi.org/10.1134/S1062359022120056

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