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The Effectiveness of Glauber’s Salt as an Antidote Therapy for the Incorporation of Radioactive Particles

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Abstract—

Using a model of artificial radioactive particles, the effectiveness of the use of a saline laxative, Glauber’s salt, as an antidote therapy agent was studied. Internal irradiation of laboratory animals (guinea pigs) and sheep was carried out under laboratory conditions with oral intake of particles simulating the radiation characteristics of young nuclear fission products, at doses that cause medium, severe, and extremely severe forms of radiation ulcerative gastroenterocolitis. During the first four days after radiation exposure, Glauber’s salt was administered to each animal once a day either as 3 mL of 20% aqueous solution (for guinea pigs) or as a 0.5 L of 12% aqueous solution (for sheep). In all animals, the drug demonstrated a statistically significant antidote effect. Glauber’s salt decreased the severity of radiation-induced ulcerative damage to the gastrointestinal tract, enhanced the speed of healing of radiation ulcers, and increased the survival of animals. The approach applied can be used in the search for new antiradiation antidotes.

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Authors and Affiliations

  1. Russian Institute of Radiology and Agroecology, Obninsk, Russia

    G. V. Kozmin & S. G. Shapovalov

  2. Ogarev Mordovia State University, Saransk, Russia

    A. S. Zenkin

  3. Federal Research Center for Virology and Microbiology, Volginskii, Russia

    V. A. Budarkov

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  1. G. V. Kozmin
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  2. S. G. Shapovalov
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  3. A. S. Zenkin
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  4. V. A. Budarkov
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Correspondence to G. V. Kozmin.

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Statement on the welfare of animals. In experimental studies, all animals were treated in strict accordance with the basic ethical and legislative considerations of the general provisions on the use of experimental animals.

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Translated by N. Ruban

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Kozmin, G.V., Shapovalov, S.G., Zenkin, A.S. et al. The Effectiveness of Glauber’s Salt as an Antidote Therapy for the Incorporation of Radioactive Particles. Biol Bull Russ Acad Sci 49, 2043–2054 (2022). https://doi.org/10.1134/S1062359022110127

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