Abstract
The early delayed effects of accelerated carbon ions and protons on the cognitive functions of mice using tests of the total activity, spatial learning, and long-term and short-term hippocampal-dependent memory were studied. The obtained results showed that irradiated animals do not develop an altered behavioral pattern: the level of anxiety is not increased, the exploratory model of behavior is clearly pronounced, and there is no deficiency of hippocampal-dependent memory. However, the long-term memory test revealed fewer errors in finding an escape box in a group of animals irradiated with protons compared to the control animals and mice irradiated with carbon ions. The results may indicate a better preservation of memory traces under these conditions.
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Statement on the welfare of animals. The study was approved by the Biosafety and Bioethics Commission of the ITEB RAS (protocol no. 23). The experiments were carried out in accordance with the requirements of the Federation of European Scientific Associations for the maintenance and use of laboratory animals in scientific research (FELASA).
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Sorokina, S.S., Zaichkina, S.I., Rozanova, O.M. et al. The Early Delayed Effect of Accelerated Carbon Ions and Protons on the Cognitive Functions of Mice. Biol Bull Russ Acad Sci 47, 1651–1658 (2020). https://doi.org/10.1134/S1062359020120109
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DOI: https://doi.org/10.1134/S1062359020120109