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Involvement of Recovery Processes in the Effects of Radioprotectors at the Cellular and Organismal Levels

  • MATERIALS FROM THE INTERNATIONAL CONFERENCE “RADIATION EXPOSURE-RELATED PROBLEMS OF CHEMICAL PROTECTION AND REPAIR” (DUBNA, 30–31 MAY, 2018)
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Abstract

A correlation between the effectiveness of the radioprotective action of cysteamine with the radiosensitivity of cells and their ability to recover from radiation damage was demonstrated for diploid yeast cells of S. cerevisiae. To demonstrate the involvement of the recovery processes in the mechanism for radioprotective action of the T1023 compound in animals, data on the survival of clonogenic bone marrow cells of mice exposed to ionizing radiation are presented. It is shown that the radioprotective effect of this compound can be realized not only at the physicochemical stage of formation of radiation damage due to a decrease in the oxygen content in tissues but also due to the post-radiation cell recovery at the biochemical stage. This is confirmed by the presence of the sigmoid part of the dose-response curve in the region of low doses of ionizing radiation.

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Funding

This publication was prepared with the support of the Russian President’s grant MK-872.2018.4 (Agreement no. 075-02-2018-570), as well as within the scientific project of the Russian Foundation for Basic Research and the Kaluga Region Government no. 18-413-400004a(p).

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Authors and Affiliations

  1. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia

    M. V. Filimonova, E. S. Evstratova, V. M. Makarchuk, L. I. Shevchenko, A. S. Filimonov & V. G. Petin

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  1. M. V. Filimonova
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  2. E. S. Evstratova
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  3. V. M. Makarchuk
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  4. L. I. Shevchenko
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  5. A. S. Filimonov
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  6. V. G. Petin
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Corresponding author

Correspondence to V. G. Petin.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Filimonova, M.V., Evstratova, E.S., Makarchuk, V.M. et al. Involvement of Recovery Processes in the Effects of Radioprotectors at the Cellular and Organismal Levels. Biol Bull Russ Acad Sci 46, 1619–1624 (2019). https://doi.org/10.1134/S1062359019120033

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  • DOI: https://doi.org/10.1134/S1062359019120033

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