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Prognosis of Post-Radiation Dynamics of Blood Neutrophil Count in Cases of Acute Uneven Irradiation (Cytogenetic Studies)

  • RADIATION CYTOGENETICS
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Abstract—

The results of applying the method of prognosis of post-radiation curves of neutrophil count dynamics in the blood after acute nonuniform human irradiation based on the use of a special computer program and the results of cytogenetic analysis of the cultures of peripheral blood lymphocytes are presented. The computer program converts the distribution of the cells by the number of dicentrics in them into the distribution of lymphocytes by dose received. Data obtained from 10 patents injured in six different radiation incidents were processed. To take into account radiation-induced proliferation delay and interphase cell death, correction of the observed distributions of dicentric chromosomes was carried out. The comparison of real and predicted curves of neutrophil count dynamics indicates in general their satisfactory compliance.

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  1. State Research Center Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia

    V. Yu. Nugis

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by A. Barkhash

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Nugis, V.Y. Prognosis of Post-Radiation Dynamics of Blood Neutrophil Count in Cases of Acute Uneven Irradiation (Cytogenetic Studies). Biol Bull Russ Acad Sci 46, 1512–1523 (2019). https://doi.org/10.1134/S1062359019110074

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