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The Study of Cognitive-Stimulating Activity of Fluorinated Tetrahydrocarbazole Derivatives and Behavioral Responses in Transgenic Tg6799 Mice with Alzheimer’s Disease

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Abstract

The cognitive-stimulating, neuroprotective effects of promising fluorinated tetrahydrocarbazole derivatives (CA-7043x and CA-7050x) on the hippocampus-dependent memory of outbred mice (CD1) and transgenic Tg6799 mice, as well as their effect on anxiety, locomotor activity, and orienting-exploratory behavior of animals, were studied. It was found that both compounds have a pronounced cognitive-stimulating effect on CD1 mice, but do not show neuroprotective effects on memory support in Tg6799 mice. It is noted that, in the open-field test, the CA-7050x compound has a positive effect on the orientating behavior, and the CA-7043x compound has a positive effect on the exploratory response in the nontransgenic control.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    N. S. Nikolaeva, A. V. Maltsev, R. K. Ovchinnikov, V. B. Sokolov, A. Yu. Aksinenko, E. V. Bovina & A. S. Kinzirsky

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  1. N. S. Nikolaeva
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  2. A. V. Maltsev
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  3. R. K. Ovchinnikov
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  4. V. B. Sokolov
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  5. A. Yu. Aksinenko
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  6. E. V. Bovina
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Correspondence to N. S. Nikolaeva.

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Nikolaeva, N.S., Maltsev, A.V., Ovchinnikov, R.K. et al. The Study of Cognitive-Stimulating Activity of Fluorinated Tetrahydrocarbazole Derivatives and Behavioral Responses in Transgenic Tg6799 Mice with Alzheimer’s Disease. Biol Bull Russ Acad Sci 46, 268–276 (2019). https://doi.org/10.1134/S1062359019030075

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