Abstract
The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4–10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.
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Original Russian Text © N.Yu. Glazova, E.A. Sebentsova, D.M. Manchenko, L.A. Andreeva, L.V. Dergunova, N.G. Levitskaya, S.A. Limborska, N.F. Myasoedov, 2018, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2018, No. 4.
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Glazova, N.Y., Sebentsova, E.A., Manchenko, D.M. et al. The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats. Biol Bull Russ Acad Sci 45, 394–399 (2018). https://doi.org/10.1134/S1062359018040040
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DOI: https://doi.org/10.1134/S1062359018040040