Biology Bulletin

, Volume 45, Issue 2, pp 186–191 | Cite as

Chronic Mild Stress Increases the Expression of Genes Encoding Proinflammatory Cytokines in the Rat Brain

  • M. Yu. Stepanichev
  • D. I. Peregud
  • A. O. Manolova
  • N. A. Lazareva
  • M. V. Onufriev
  • N. V. Gulyaeva
Animal and Human Physiology


Alterations in the expression of genes encoding interleukins IL-1α, IL-1β, IL-6, and tumor necrosis factor-α (TNF-α) were studied in the rat brain in a model of a depressive disorder. We found that the signs of a depressionlike condition in rats, subjected to eight weeks of chronic mild unpredictable stress, were accompanied by increased IL-1α and IL-1β mRNAs levels in the neocortex, hippocampus, and brainstem and a decreased IL-6 mRNA level in the brainstem as compared to those observed in the control animals. We did not find any changes in the level of TNF-α mRNA. We suggest that region-specific alterations in the expression of cytokine genes, specifically, the most prominent increase in IL-1β expression, reflects greater vulnerability of chronically stressed animals to neuroinflammatory processes.


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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • M. Yu. Stepanichev
    • 1
  • D. I. Peregud
    • 2
  • A. O. Manolova
    • 1
  • N. A. Lazareva
    • 1
  • M. V. Onufriev
    • 1
    • 3
  • N. V. Gulyaeva
    • 1
    • 3
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia
  2. 2.Research Institute on Addictions, Division of Serbskii Federal Medical Research Center on Psychiatry and AddictionMinistry of Health of the Russian FederationMoscowRussia
  3. 3.Moscow Research and Clinical Center for NeuropsychiatryMoscow Department of HealthcareMoscowRussia

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