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Peptide regulation of metabolic processes under hypercholesterinemia conditions of an organism

  • Animal and Human Physiology
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Abstract

The participation of short glyproline peptides in regulating the metabolic processes of the body has been established. Experimental hypercholesterolemia and the development of metabolic syndrome in rats was caused by including foods with excess animal fat and carbohydrates in the diet, which eventually led to increased levels of cholesterol, triglycerides, and the atherogenic lipoproteins; hypercoagulation; and increased blood sugar. It was noted that glyprolines with different structures possess a unique combined effect on fat and carbohydrate metabolism, normalizing the characteristics of the lipid profile and blood sugar and protecting the organisms of animals from increased blood clotting. The idea of peptide regulation of the hemostatic system and metabolism of fats and carbohydrates in the development of metabolic syndrome was formulated.

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Authors and Affiliations

  1. Moscow State University, Faculty of Biology, Moscow, 119991, Russia

    L. A. Lyapina, M. E. Grigor’eva, T. Yu. Obergan & T. A. Shubina

  2. Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 2, Moscow, 123182, Russia

    L. A. Andreeva & N. F. Myasoedov

Authors
  1. L. A. Lyapina
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  2. M. E. Grigor’eva
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  3. T. Yu. Obergan
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  4. T. A. Shubina
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  5. L. A. Andreeva
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  6. N. F. Myasoedov
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Correspondence to L. A. Lyapina.

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Original Russian Text © L.A. Lyapina, M.E. Grigor’eva, T.Yu. Obergan, T.A. Shubina, L.A. Andreeva, N.F. Myasoedov, 2015, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2015, No. 6, pp. 634–644.

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Lyapina, L.A., Grigor’eva, M.E., Obergan, T.Y. et al. Peptide regulation of metabolic processes under hypercholesterinemia conditions of an organism. Biol Bull Russ Acad Sci 42, 546–555 (2015). https://doi.org/10.1134/S1062359015060060

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  • DOI: https://doi.org/10.1134/S1062359015060060

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