Macrosmatic animals (dogs and mice) have been proved to be able to distinguish between the urine or feces of mice with transplanted hepatocellular carcinoma and those of healthy mice by odor. The chemical composition of animal excreta was found to change with tumor growth; however, it is not clear yet if this results from tumor growth itself, inflammation, or immune response. We suggested that the use of the ability of macrosmatic animals to compare odor mixtures combined with mouse cancer models is a promising trend in the search for new tumor markers.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Ackerl, K., Atzmüller, A., and Grammer, K., The scent of fear, Neuroendocrinol. Lett., 2001, vol. 23, pp. 79–84.
Amal, H., Ding, L., Liu, B.B., et al., The scent fingerprint of hepatocarcinoma: in-vitro metastasis prediction with volatile organic compounds (VOCs), Int. J. Nanomed., 2012, vol. 7, pp. 4135–4146.
Anisimov, V.N., Ukraintseva, S.V., and Yashin, A.I., Cancer in rodents: does it tell us about jarcer in humans?, Nat. Rev. Cancer, 2005, vol. 5, pp. 807–819.
Arakawa, H., Cruz, S., and Deak, T., From models to mechanisms: odorant communication as a key determinant of social behavior in rodents during illness-associated states, Neurosci. Biobehav. Rev., 2011, vol. 35, pp. 1916–1928.
Boedeker, E., Friedel, G., and Walles, T., Sniffer dogs as part of a bimodal bionic research approach to develop a lung cancer screening, Interact. Cardiovasc. Thorac. Surg., 2012, vol. 14, pp. 511–515.
Bransbury, A.J., Church, M.R.T., and Church, J.C.T., Olfactory detection of human bladder cancer by dogs: proof of principle study, BMJ, 2004, vol. 329, pp. 712–717.
Cornu, J.N., Cancal-Tassin, G., Ondet, V., et al., Olfactory detection of prostate cancer by dogs sniffing urine: a step forward to early diagnosis, Eur. Urol., 2011, vol. 59, pp. 197–201.
Gordon, R.T., Schatz, C.B., Myers, L.J., et al., The use of canines in the detection of human cancers, J. Altern. Compl. Med., 2008, vol. 14, pp. 61–67.
Hakim, G.M., Broza, Y.Y., Billan, S., et al., Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors, Br. J. Cancer, 2010, vol. 103, pp. 542–551.
Hanai, Y., Shimono, K., Matsumura, K., et al., Urinary volatile compounds as biomarkers for lung cancer, Biosci. Biotechnol. Biochem., 2012a, vol. 76, pp. 679–684.
Hanai, Y., Shimono, K., Oka, H., et al., Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice, Cancer Cell Int., 2012b, vol. 12, pp. 7–19.
Havlicek, J.1. and Roberts, S.C., MHC-correlated mate choice in humans: a review, Psychoneuroendocrinology, 2009, vol. 34, no. 4, pp. 497–512.
Heth, G. and Todrank, J., Individual odour similarities across species parallel phylogenetic relationships in the S. ehrenbergi superspecies of mole-rats, Anim. Behav., 2000, vol. 60, pp. 789–795.
Horvath, G., Järverud, G., Järverud, S., and Horváth, I., Human ovarian carcinomas detected by specific odor, Integrative Cancer Therapies, 2008, vol. 7, pp. 76–80.
Horváth, I., Lázár, Z., Gyulai, N., et al., Exhaled biomarkers in lung cancer, Eur. Respir. J., 2009, vol. 34, pp. 261–275.
Horvath, G., Andersson, H., and Paulsson, G., Characteristic odour in the blood reveals ovarian carcinoma, BMC Cancer, 2010, vol. 10, p. 643.
Hussain, S.A., Ferry, D.R., El-Gazzaz, G., et al., Hepatocellular carcinoma, Ann. Oncol., 2001, vol. 12, pp. 161–172.
Jemal, A., Bray, F., Center, M.M., et al., Global cancer statistics, CA Cancer J. Clin., 2011, vol. 61, pp. 69–90.
Koczulla, R., Hattesohl, A., Biller, H., et al., Comparison of four identical electronic noses and three measurement set-ups, Pneumologie, 2011, vol. 65, pp. 465–470.
Korenevskii, Yu., Examination of olfactory traces in investigative and judicial practice, Ros. Yustitsiya, 2000, no. 8, p. 29.
Krutova, V.I., Sulimov, K.T., and Zinkevich, E.P., The time of appearance of individual odor in the ontogeny of the gray rat (Rattus norvegicus) according to dog training analysis, Sensorn. Sistemy, 1997, vol. 11, no. 3, pp. 340–345.
Kuano, M., Mendez, E., and Furton, K.G., Development of headspace SPME method or analysis of volatile organic compounds present in human biological specimens, Anal. Bioanal. Chem., 2011, vol. 400, pp. 1817–1826.
Kwak, J., Gallagher, M., Ozdener, M.H., et al., Volatile biomarkers from human melanoma cells, J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2013, vol. 931, pp. 90–96.
Lazarevich, N.L., Cheremnova, O.A., Varga, E.V., et al., Progression of HCC in mice is associated with a down-regulation in the expression of hepatocyte nuclear factors, Hepatology, 2004, vol. 39, pp. 1038–1047.
Matsumura, K., Opiekun, M., Oka, H., et al., Urinary volatile compounds as biomarkers for lung cancer: a proof of principle study using odor signatures in mouse models of lung cancer, PLoS One, 2010, vol. 5, p. e8819.
McCulloch, M., Jezierski, T., Broffman, M., et al., Diagnostic accuracy of canine scent detection in early- and latestage lung and breast cancers, Interact. Cancer. Ther., 2006, vol. 5, pp. 30–39.
O’Neill, H.J., Gordon, S.M., O’Neill, M.H., et al., A computerized classification technique for screening for the presence of breath biomarkers in lung cancer, Clin. Chem., 1988, vol. 34, no. 8, pp. 1613–1618.
Penn, D. and Potts, W.K., Chemical signals and parasite-mediated sexual selection, Trends Ecol. Evol., 1998, vol. 13, pp. 391–396.
Persaud, K. and Dodd, G., Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose, Nature, 1982, vol. 299, pp. 352–355.
Qin, T., Liu, H., Song, Q., et al., The screening of volatile markers for hepatocellular carcinoma, Cancer Epidemiol. Biomark. Prev., 2010, vol. 19, pp. 2247–2253.
Rivière, S., Challet, L., Fluegge, D., et al., Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors, Nature, 2009, vol. 459, pp. 574–577.
Rodionova, E.I., Minor, A.V., Sulimov, K.T., and Kogun, G.A., Dogs are able to recognize insect individuals by odour, Chem. Senses, 2009, vol. 34, no. 3, p. E64.
Schoon, G.A.A., Scent identification lineups by dogs (Canis familiaris): experimental design and forensic application, Appl. Anim. Behav. Sci., 1996, vol. 49, pp. 257–267.
Schoon, A. and Haak, R., K9 Suspect Discrimination: Training and Practicing Scent Identification Line-Ups, Calgary, Alberta, Canada: Detselig Enterprises, 2002.
Sokolov, V.E., Sulimov, K.T., and Krutova, V.I., Dog identification of individual odors in live activity traces of four species of vertebrates, Izv. Akad. Nauk SSSR, Ser. Biol., 1990, no. 4, pp. 56–64.
Sonoda, H., Kohnoe, S., Yamazato, T., et al., Colorectal cancer screening with odour material by canine scent detection, Gut, 2011, vol. 60, pp. 814–819.
Tisch, U. and Haick, H., Nanomaterials for cross-reactive sensor arrays, MRS Bull., 2010, vol. 35, p. 797.
Walczak, M., Jezierskie, T., Górecka-Bruzda, A., et al., Impact of individual training parameters and manner of taking breath odor samples on the reliability of canines as cancer screeners, J. Vet. Behav., 2012, vol. 7, pp. 283–294.
Williams, M. and Johnston, J.M., Training and maintaining the performance of dogs (Canis familiaris) on an increasing number of odor discriminations in a controlled setting, Appl. Anim. Behav. Sci., 2002, vol. 78, pp. 55–65.
Xue, R., Dong, L., Zhang, S., et al., Investigation of volatile biomarkers in liver cancer blood using solid-phase microextraction and gas chromatography/mass spectrometry, Rapid Commun. Mass Spectrom., 2008, vol. 22, pp. 1181–1186.
Yamazaki, K. and Beauchamp, G.K., Genetic basis for MHC-dependent mate choice, Adv. Genet., 2007, vol. 59, pp. 129–145.
Original Russian Text © E.I. Rodionova, M.Yu. Kochevalina, E.V. Kotenkova, O.V. Morozova, G.A. Kogun’, E.L. Bataeva, A.V. Ambaryan, 2015, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2015, No. 3, pp. 293–301.
About this article
Cite this article
Rodionova, E.I., Kochevalina, M.Y., Kotenkova, E.V. et al. Detection of volatile organic compounds associated with hepatocellular carcinoma by macrosmatic animals: Approaches to the search for new tumor markers. Biol Bull Russ Acad Sci 42, 239–245 (2015). https://doi.org/10.1134/S1062359015030103
- Volatile Organic Compound
- Biology Bulletin
- Healthy Mouse
- Formyl Peptide Receptor
- Aviation Security